Results 51 to 60 of about 94,169 (259)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Interventions to safely and effectively reduce (taper) use of opioids in chronic non-cancer pain: a systematic review

Health Technology Assessment
Background Opioids are prescribed for the management of chronic non-cancer pain, but they have important limitations and evidence does not support long-term use. People taking opioids therefore need support to reduce or stop use.
Ruaraidh Hill, Michelle Maden, Rui Duarte, Sam Eldabe, Su Golder, Marty Chaplin, Beth Shaw, Katy Sutcliffe, Adam Todd, Rebecca Bresnahan, Katherine Edwards, Janette Greenhalgh, Juliet Hounsome, Jack Trafford, Nefyn Williams   +14 more
doaj   +1 more source

Swimming coaches' perceptions and practices on periodization, performance monitoring, and training management

Frontiers in Sports and Active Living
IntroductionThis study examined the beliefs and practices of Spanish national swimming coaches regarding season planning, aiming to gain a deeper understanding of how they organize training throughout the year.MethodsA total of 18 coaches participated ...
Cristina Cano-Cuartero, Alejandro López-Hernández, Sergio Rodríguez-Barbero, Sergio Rodríguez-Barbero, José María González-Ravé   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study.

, 2020
Rationale: There is a need to minimize oral corticosteroid (OCS) use in patients with asthma to prevent their costly and burdensome adverse effects. Current guidelines do not provide recommendations for OCS tapering in patients with asthma.Objectives: To
Menzies-Gow, A., Suehs, CM, Bourdin, A, Bleecker, ER, Menzies-Gow, A, Gurnell, M, Bleecker, Eugene, Suehs, Carey, Canonica, G.W., Brussino, L., Canonica, Giorgio Walter, Canonica, GW, Bourdin, A., Suehs, Carey M., Bleecker, Eugene R, Suehs, Carey M, Bleecker, E.R., Menzies-Gow, Andrew, Price, D., Bourdin, Arnaud, Bleecker, Eugene R., Gurnell, M., Oral Corticosteroids Tapering Delphi Expert Panel, Gurnell, Mark, Price, D, Price, David, Suehs, C.M.   +26 more
core   +1 more source

Tapering methods used in the deprescribing services.

, 2023
Tapering methods used in the deprescribing services.
Anne Guy (9627252), Jo Lomani (14274927), James Davies (558344), Ruth E. Cooper (6862412), Michael Ashman (14797250), Joanna Moncrieff (275125), Mark Horowitz (3747628), Nicola Morant (596148)   +7 more
core   +1 more source

Calculation of sharpness in lung images of pleural effusion patients and normal lung images using the thresholding segmentation method

Gravity: Jurnal Ilmiah Penelitian dan Pembelajaran Fisika, 2020
Research on the calculation of tapering from lung's images of patients with pleural effusion and normal lungs has been carrying out using the thresholding segmentation method.
Indah Nurhidayati, Sinta M Siagian
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source