Results 241 to 250 of about 4,410,863 (269)

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

Nature Reviews Drug Discovery, 2010
Aimee L. Jackson, Peter S Linsley
exaly  

CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off-Target Evaluation, and Strategies to Mitigate Off-Target Effects

Advanced Science, 2020
Hakim Manghwar, Shuangxia Jin, Xianlong Zhang   +2 more
exaly  

Impact of target interactions on small-molecule drug disposition: an overlooked area

Nature Reviews Drug Discovery, 2018
Andrés Olivares-Morales, Thierry Lave, Dennis A Smith   +2 more
exaly  

Multiscale patch-based contrast measure for small infrared target detection

Pattern Recognition, 2016
Yantao Wei, Xinge You
exaly  

Targeteer

Communications of the ACM, 1961
openaire   +2 more sources

Target identification and mechanism of action in chemical biology and drug discovery

Nature Chemical Biology, 2013
Paul A Clemons, Bridget K Wagner, Monica Schenone   +2 more
exaly  

NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma

Signal Transduction and Targeted Therapy, 2020
Hu Zhao, Robert M Hoffman, Yanyu Jiang
exaly  

Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases

Biotechnology Advances, 2017
Reinhard Fischer, Julia Jansing, Luisa Bortesi   +2 more
exaly  

A Local Contrast Method for Small Infrared Target Detection

IEEE Transactions on Geoscience and Remote Sensing, 2014
C L Philip Chen, Yantao Wei, Yuan Yan Tang   +2 more
exaly  

A new target for treating progeria

Nature Reviews Drug Discovery, 2013
Harrison Charlotte
exaly