Results 141 to 150 of about 545,656 (315)

Tryptophan: antioxidant or target of oxidative stress? A quantum chemistry elucidation

, 2014
Adriana Pérez‐González, Leonardo Muñoz‐Rugeles, J. Raúl Alvarez‐Idaboy   +2 more
openalex   +2 more sources

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5 [PDF]

, 2019
Arduino Mangoni, Jean Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Sousa, Paula Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Luque, Jarkko Rautio, Rafik Karaman, M. Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi Agrofoglio, Rino Ragno, Diego Muñoz-Torrero   +25 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Artificial Intelligence and Machine Learning in Medicinal Chemistry and Validation of Emerging Drug Targets

, 2021
Sameer Quazi, Rohit Jangi
openalex   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cyclic transformation of stable/metastable nucleic acid structures enables dynamic monitoring of ATP in living cells. [PDF]

Chem Sci
Su ML, Yang J, Yang WG, Ye ZX, Wang RW, Qin JM, Song DQ, Yuan R, Ma PY, Zhuo Y, Yang C, Liang WB.   +11 more
europepmc   +1 more source

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies

, 2019
Dean Tyler
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Organic Heterojunction Nanoparticles: Photoinduced Charge Transfer and Melanin-Amplified ROS Generation for Melanoma Photodynamic Therapy

JACS Au
Quanyi Jin, Haoyi Wu, Wei Zheng, Qian Lin, Beibei Liu, Aijuan Kuang, Sicong Wang, Haining Tian, Xuan Zhu, Aijie Liu   +9 more
doaj   +1 more source

Correction: Lutskovich et al. Comparative Preclinical Analysis of Anti-B7-H3 CAR-T Cells Targeting Neuroblastoma. <i>Biomedicines</i> 2025, <i>13</i>, 2130. [PDF]

Biomedicines
Lutskovich DV, Meleshko AN, Stepanova VM, Dormeshkin DO, Rubtsov YP.   +4 more
europepmc   +1 more source