Results 151 to 160 of about 545,656 (315)

Fine Chemistry targeting Genome

Journal of Synthetic Organic Chemistry, Japan, 2020
openaire   +2 more sources

Medicinal Chemistry Studies Applied to Protein Targets

Current Protein & Peptide Science, 2019
Luciana, Scotti, Marcus T, Scotti
openaire   +2 more sources

Corrigendum to “Nutrient composition and functional constituents of daylily from different producing areas based on widely targeted metabolomics” [Food Chemistry: X Nutrient composition and functional constituents of daylily from different producing areas based on widely targeted metabolomics 21 (2024) 101239/FOCHX-D-23-01093]

Haizhen Wang, Mengying Zhao, Zhen Wu, Nannan Qin, Yongxia Fu, Shang Guo   +5 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Novel vinyl-modified RGD conjugated silica nanoparticles based on photo click chemistry for in vivo prostate cancer targeted fluorescence imaging

, 2019
Hanrui Li, Ke Li, Qi Zeng, Yun Zeng, Dan Chen, Liaojun Pang, Xueli Chen, Yonghua Zhan   +7 more
openalex   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evolution of siRNA Therapeutics: From Mechanistic Foundations to Clinical Expansion. [PDF]

Pharmaceutics
Le QV, Shim G.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Efficient preparation of size-controlled sodium alginate microspheres <i>via</i> adaptive Bayesian optimization of the spray process. [PDF]

RSC Adv
Feng S, Liu J, Li Z, Tao S.
europepmc   +1 more source

Correction to “Structure-Informed Design of High-Cooperativity PROTAC Targeting SARS-CoV-2 RdRp via Click Chemistry and Enhanced Sampling Simulations” [PDF]

Kiran Shehzadi, Q Chen, Yue Ran, Iqra Kalsoom, Jingyue Dong, Peifeng Gao, Irfan Muhammad, Ming-jia Yu, Zihui Meng, Jian-hua Liang   +9 more
openalex   +1 more source