Results 171 to 180 of about 545,656 (315)

Integrating trace element chemistry, and sulfur isotope systematics of alunite in the Zhule (Xizang), central Lhasa terrane: implications for porphyry-high sulfidation epithermal Cu-Au exploration targeting

Jin-ling Xie, Ju-xing Tang, Zhi-bo Liu, Qing-fei Sun, Li-rui Yu, Chang-jiang Yuan, Xu-kun Yan, Xiao-yan Zhao, Qing-qing Yin, Bin Kang, Qi-lian Chen, Nan Wang   +11 more
openalex   +1 more source

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches

, 2018
Nikki A. Thiele, Justin J. Wilson
openalex   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

One-Pot Enzymatic ADDing of Click Chemistry Handles for Protein Immobilization and Bioconjugation of Small and Biomolecules. [PDF]

Bioconjug Chem
Widodo WS, Fan X, Fürst MJLJ.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening. [PDF]

Chembiochem
Csorba N, Ábrányi-Balogh P, Orgován Z, Szalai TV, Ferenczy GG, Kollár L, Péczka N, Imre T, Simon J, Szabó P, Schlosser G, Hrast M, Gobec S, Ivanova V, Galdeano C, Kopranovic A, Neumann M, Meyer-Almes FJ, Keserű GM.   +18 more
europepmc   +1 more source

Dual pH-Responsive Calcium Phosphate NanoparticlesConjugated with Folate by CuAAC Click Chemistry for Targeted GemcitabineDelivery to Cancer Cells

Thales R. Machado (6274208), Aileen Winter (18541526), Kateryna Loza (6667139), Kathrin Kostka (14662025), Valtencir Zucolotto (1644601), Matthias Epple (567089)   +5 more
openalex   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Click Chemistry Mediated Immune Synapse Augmentation in Natural Killer Cell-Cancer Membrane Engagement and Facilitated Anticancer Efficacies of Natural Killer Cell Therapy. [PDF]

Biomater Res
Noh KM, Jangid AK, Kim E, Kim K.
europepmc   +1 more source

Design and synthesis of novel Cystic Fibrosis (CF) modulators - Development of novel inhibitors of the anti-infective target DXS using Dynamic Combinatorial Chemistry (DCC)

, 2020
Melissa Guardigni
openalex   +2 more sources