Results 231 to 240 of about 545,656 (315)

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

ACS Omega
Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch   +10 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

CAG-targeting artificial miRNA with reduced off-target risk for efficient lowering of pathogenic polyglutamine proteins. [PDF]

NAR Mol Med
Pewinska-Kolodziejczak M, Kotowska-Zimmer A, Przybyl L, Wronka D, Karlik A, Smuszkiewicz M, Balcerek J, Suszynska-Zajczyk J, Piaszyk-Borychowska A, Urbanek-Trzeciak M, Sablok G, Kozlowska E, Podkowinski J, Fiszer A, Kozlowski P, Handschuh L, Olejniczak M.   +16 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Bayesian Optimization of Solvent-Free Thermal Amidation via Reactive Extrusion. [PDF]

Chemistry
Lavayssiere M, Bantreil X, Lamaty F.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Induced-proximity therapeutics for targeted protein and RNA degradation: An organic chemistry Perspective-A review. [PDF]

Curr Res Struct Biol
Rizehbandi M, Dadfar E, Rezaei Nami M, Rezaei Nami M, Rezaei Nami M.   +4 more
europepmc   +1 more source

1,908,879 Allosteric Peptide Modulator Candidates Targeting Melatonin Receptors MT1 and MT2 with Predicted Pharmacology, Universal Synthesis Protocols, Universal Binding-Affinity and Functional Assay Protocols, WIPO ST.26 Sequence Listing, and Per-Composition §102 Public-Domain Dedication Across 35,198 Unique Backbones × 90 Form-Variant Chemistries

Coracle Research
openalex   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Editorial: Emerging trends in biosensors: bridging chemistry and practical applications. [PDF]

Front Chem
Wang R.
europepmc   +1 more source