Results 241 to 250 of about 545,656 (315)

Establishing the Chelation Chemistry of Antimony-119 for Targeted Auger Therapy

USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP), Jonathan Engle, Nikki A. Thiele   +2 more
openalex   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Concept-driven strategies in target-oriented synthesis. [PDF]

Beilstein J Org Chem
Chen DY, Li C, Tang Y.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

High-dimensional CRISPR-SERS interactomics tracks the topological evolution of plant viral pathogenesis and therapeutic response. [PDF]

Chem Sci
Dou Y, Wu G, Li J, Wang Y, Chen N, Xu T, Cai X, Zhang T, Zhang X, Li X, Li J, Sun Y.   +11 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs. [PDF]

Beilstein J Org Chem
Day-Riley S, Krajcovicova S, Sokhal AR, Venne JL, Brear P, Hyvönen M, Whitehurst BC, Carroll JS, Spring DR.   +8 more
europepmc   +1 more source

Bioorganic Chemistry of Peptidoglycan as the Target of Antibacterials

Trends in Glycoscience and Glycotechnology, 2010
openaire   +1 more source

Target Species Selection for Dynamic Adaptive Chemistry Simulations

, 2014
Nicholas Curtis
openalex   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source