Results 261 to 270 of about 545,656 (315)

LipophilicCationsas Mitochondria-Targeting Moieties:Recent Progress and Design Principles for Medicinal Chemistry

Ivan Džajić (9647126), Tihomir Tomašič (1550395), Luis A. Pardo (8854499), Lucija Peterlin Mašič (14420614), Andrej Emanuel Cotman (3924452)   +4 more
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Correction: Furin as target for suppression of mosquito-borne viruses. [PDF]

Virol J
Centurión A, Omokungbe B, Oberpaul M, Dersch L, Stiehler S, Chambers C, Lechner M, Lüddecke T, Vilcinskas A, Steinmetzer T, Hardes K.   +10 more
europepmc   +1 more source

NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate. [PDF]

Cell Chem Biol
Zhang Y, Lindner H, So B, Chen Z, Li H, Xu J, Wang J, Xu J, Petre AM, Distefano MD, Núñez G, Lin H.   +11 more
europepmc   +1 more source

Multicomponent Reactions in 11C/12C Chemistry : – Targeting the Angiotensin II Subtype 2 Receptor

, 2016
Marc Y. Stevens
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The role of coordination chemistry in the development of target-specific radiopharmaceuticals

Chemical Society Reviews, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shuang Liu
exaly   +3 more sources

Medicinal chemistry of target family-directed masterkeys

Drug Discovery Today, 2003
The majority of pharmaceutically relevant drug targets cluster into densely populated target families, thus offering a novel approach that complements the currently favoured screening paradigm in medicinal chemistry. This approach uses a privileged structure concept whereby molecular masterkeys are developed that account for a target family wide ...
exaly   +3 more sources

Supramolecular “Click Chemistry” for Targeting in the Body

Bioconjugate Chemistry, 2021
The fields of precision imaging and drug delivery have revealed a number of tools to improve target specificity and increase efficacy in diagnosing and treating disease. Biological molecules, such as antibodies, continue to be the primary means of assuring active targeting of various payloads. However, molecular-scale recognition motifs have emerged in
Christopher J. Addonizio, Brant D. Gates, Matthew J. Webber   +2 more
openaire   +2 more sources

Using Chemistry to Target Neuroblastoma

ACS Chemical Neuroscience, 2017
Neuroblastoma is a cancer of the neural crest almost exclusively seen in childhood. While children with single, small primary tumors are often cured with surgery alone, the 65% of children with neuroblastoma whose disease has metastasized have less than a 50% chance of surviving five years after diagnosis.
Jeanne N. Hansen, Xingguo Li, Y. George Zheng, Louis T. Lotta, Abhishek Dedhe, Nina F. Schor   +5 more
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Converter target chemistry – A new challenge to radioanalytical chemistry

Applied Radiation and Isotopes, 2018
The 1-2 GeV proton induced spallation reaction on the high Z materials like Hg, or lead bismuth eutectic (LBE), popularly known as converter targets, will produce strong flux of fast neutrons which would further react with fissile materials to produce intense radioactive ion beam (RIB).
Dibyasree, Choudhury, Susanta, Lahiri
openaire   +2 more sources