Results 271 to 280 of about 545,656 (315)
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Carbonic anhydrases as targets for medicinal chemistry
Bioorganic & Medicinal Chemistry, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SUPURAN, CLAUDIU TRANDAFIR +1 more
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Applications of covalent chemistry in targeted protein degradation
Chemical Society Reviews, 2022This review summarizes the recent work of covalent chemistry in targeted protein degradation and describes the concept, pros and cons, development, and the outlook of covalent PROTACs.
Dong Lu +7 more
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Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria
Current Topics in Medicinal Chemistry, 2022ABSTRACT: The discovery of antibiotics was a revolutionary feat that provided countless health bene-fits. The identification of penicillin by Alexander Fleming initiated the era of antibiotics, represent-ed by constant discoveries that enabled effective treatments for the different classes of diseases caused by bacteria.
Kadja Luana Chagas Monteiro +6 more
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The Offer of Chemistry to Targeted Therapy in Cancer
Recent Patents on Biotechnology, 2011Cancer therapy is facing the big challenge of destroying selectively tumour cells without harming the normal tissues. Chemotherapy was trying from the beginning to kill malignant cells because of their proliferative activity since normal cells are in general quiescent.
Ikram, Jemel +3 more
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Design of targeting ligands in medicinal inorganic chemistry
Chemical Society Reviews, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tim, Storr +2 more
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The Medicinal Chemistry of Agents Targeting Monoacylglycerol Lipase
Current Topics in Medicinal Chemistry, 2008Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological ...
Alma, Viso +2 more
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New Targets in Fullerene Chemistry
ECS Meeting Abstracts, 2009Abstract not Available.
Nazario Martin +2 more
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Covalent chemistry in targeted protein degradation
Advanced Drug Delivery ReviewsTargeted protein degradation (TPD) has revolutionized drug discovery by enabling the selective removal of specific proteins within and outside cells through the cell's natural degradation pathways. While various TPD modalities have demonstrated immense promise, the integration of covalent chemistry is rapidly emerging as a crucial approach to enhance ...
Jing, Tan +3 more
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Topoisomerase Targeted Agents – Chemistry to Chemotherapy
Expert Opinion on Investigational Drugs, 1998This meeting demonstrated the extent of new knowledge on the interaction of topoisomerase enzymes with DNA at the molecular level, including their high level of sequence recognition and their efficient DNA cleavage and religation mechanisms. Speakers discussed the use of this new knowledge to create detailed models of enzyme/DNA/drug ternary complexes,
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From Combinatorial Chemistry to Cancer-Targeting Peptides
Molecular Pharmaceutics, 2007Several monoclonal antibodies that target cell surface receptors have gained approval by the U.S. Food and Drug Administration and are widely used in the treatment of some cancers. These include but are not limited to the anti-CD20 antibody Rituximab, used in lymphoma treatment, as well as anti-HER-2 antibody for breast cancer therapy.
Olulanu H, Aina +5 more
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