Results 281 to 290 of about 545,656 (315)

Bioinorganic Chemistry of Bismuth and Antimony:  Target Sites of Metallodrugs

Accounts of Chemical Research, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ge, R, Sun, H
openaire   +4 more sources

Click Chemistry for Target Engagement Studies

The expanding number of targeted covalent small molecule inhibitors in clinical development increases the importance of identification and quantitation of on- and off-target engagement for these molecules in order to better understand the level of target binding and inhibition and potential side effects.
Silvia, Castelli, Sonia, Troiani, Ulisse, Cucchi   +2 more
openaire   +2 more sources

Therapeutic targeting of CDK12: a medicinal chemistry perspective

Bioorganic & Medicinal Chemistry
CDK12 (Cyclin-dependent kinase 12) is a cyclin-dependent kinase that regulates gene transcription by phosphorylating the C-terminal domain of RNA polymerase II, playing a crucial role in maintaining genomic stability. Mutations or alterations in the CDK12 genome can trigger tumorigenesis and progression.
Feifei, Wang, Hongxue, Dai, Kuanxin, Wan, Mingliang, Wang   +3 more
openaire   +2 more sources

Tables of Suggested Water Chemistry Targets

2022
Tables of Suggested Water Chemistry Targets.
openaire   +1 more source

Biomedical Targeting: A Role for Supramolecular Chemistry

1994
Targeting of imaging and therapeutic agents in nuclear medicine offers an attractive application of supramolecular chemistry. We trace the conceptual development of such targeting from its beginnings in a morphologically-based approach through the present, physicochemically-based methods, where we suggest a new potential basis for targeting: redox ...
K. M. Miller, E. A. Deutsch, S. R. Cooper   +2 more
openaire   +1 more source

Novel chemistry for undruggable targets

European Journal of Medicinal Chemistry, 2015
Francesca, Milletti, Tomi K, Sawyer
openaire   +2 more sources

Scientific Advances in Non-Targeted Chemistry

2020
Presentation to the Science Advisory Panel for Constituents of Emerging Concern (CECs) in California’s Aquatic Ecosystems October ...
openaire   +1 more source

Electrochemical sensor for single-cell determination of bacteria based on target-triggered click chemistry and fast scan voltammetry

Food Chemistry, 2023
Huiqian Zhou, Tingting Hao, Yufang Hu
exaly  

Nucleic acids as templates and catalysts in chemical reactions: target-guided dynamic combinatorial chemistry and in situ click chemistry and DNA/RNA induced enantioselective reactions

Chemical Society Reviews, 2023
Puja Saha, Deepanjan Panda, Jyotirmayee Dash   +2 more
exaly  

Impact of target interactions on small-molecule drug disposition: an overlooked area

Nature Reviews Drug Discovery, 2018
Andres Olivares-Morales, Thierry Lave, Malcolm Rowland   +2 more
exaly