Results 91 to 100 of about 1,532,764 (266)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Targeted Therapies; Who Detects the Target?
Analytical Cellular Pathology, 2005 G. A. Meijer, J. J. Oudejans
openaire +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
SensorsStepped-frequency radar is an important high range resolution radar. It can achieve wide overall bandwidth with narrow instant bandwidth. When the signal-to-noise ratio is low, detection and tracking become challenging due to dense false alarms and the ...
Fei Cai, Meiyu Tang
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
EntropyTo address the challenges of radar multi-target detection in marine environments, this paper proposes an information geometry (IG)-based, two-stage track-before-detect (TBD) framework.
Jinguo Liu +4 more
doaj +1 more source
Target Driven Adaptive Loss for Infrared Small Target Detection
2025 IEEE International Conference on Image Processing (ICIP)We propose a target driven adaptive (TDA) loss to enhance the performance of infrared small target detection (IRSTD). Prior works have used loss functions, such as binary cross-entropy loss and IoU loss, to train segmentation models for IRSTD. Minimizing these loss functions guides models to extract pixel-level features or global image context. However,
Shoji, Yuho +2 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Quantum Limits of Covert Target Detection
Physical Review Letters20 pages, 5 ...
Guo Yao Tham, Ranjith Nair, Mile Gu
openaire +4 more sources