Results 201 to 210 of about 321,270 (256)

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Interleaved TMS-fMRI demonstrates target engagement for commonly used OFC targets

Brain Stimulation
Martin Tik
doaj   +1 more source

Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression - the PRIME-PRAXOL randomized controlled trial

Ventorp F, Lindahl J, Möller S, Asp M, Olsson S, Svensson M, Ängeby F, Pravdinske A, Tjernberg J, Schrey S, Ståhl D, Magnusson V, Eliasson E, Westen Dv, Deierborg T, Månsson K, Pizzagalli D, Hammar Å, Tornberg Å, Björkstrand J, Lindqvist D.   +20 more
europepmc   +1 more source

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in <i>Plasmodium falciparum</i>. [PDF]

ACS Infect Dis
Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch AKH, Mäser P, Rottmann M, Hahne H.   +7 more
europepmc   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement. [PDF]

ACS Med Chem Lett
Yu X, Lin H, Li F, Wang J, Lu D.
europepmc   +1 more source

Safety, Pharmacokinetics and Target Engagement of a Novel Brain Penetrant RIPK1 Inhibitor (SIR9900) in Healthy Adults and Elderly Participants. [PDF]

Clin Transl Sci
Gonen OM, Porter T, Wang B, Xue F, Ma Y, Song L, Sun P, Fan W, Shen Y.   +8 more
europepmc   +1 more source

Model-Informed Selection of the Recommended Phase 2 Dosage for Anti-TIGIT Immunotherapy Leveraging co-Expressed PD-1 Inhibitor Target Engagement. [PDF]

Clin Pharmacol Ther
Kareva I, Hu P, Pierre V, Kitzing T, Victor A, Richter E, Gao W, Venkatakrishnan K, Zutshi A.   +8 more
europepmc   +1 more source