Results 211 to 220 of about 321,270 (256)

Divergence between structural binding potential and cellular target engagement of neomycin on human ribosomes

Wu M, Zhu L, Wu K, Jia C, Zhang X, Zhao Z, Liu H, Yi C, Sun S, Liu K, Zhang Z, Guo L, Hou X, Li W.   +13 more
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Bispecific Complement Engagers for Targeted Complement Activation

The Journal of Immunology, 2023
Abstract Activation of the complement system represents an important effector mechanism of endogenous and therapeutic Abs. However, efficient complement activation is restricted to a subset of Abs due to the requirement of multivalent interactions between the Ab Fc regions and the C1 complex.
Dennis V Pedersen, Heidi Gytz, Mikael B L Winkler, Alessandra Zarantonello, Niklas Baumann, Annette G Hansen, Steffen Thiel, Gregers R Andersen, Thomas Valerius, Nick S Laursen   +9 more
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The versatility of boron in biological target engagement

Nature Chemistry, 2017
Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease ...
Diego B, Diaz, Andrei K, Yudin
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A Study of Methods for Engaging Moving Targets

Human Factors: The Journal of the Human Factors and Ergonomics Society, 1983
This research focused on two methods for engaging moving targets: tracking and trapping. Interest was in determining the conditions under which either method would prove superior. It was hypothesized that a shooter's ability as well as the speed and range of the target might affect the outcome.
Joel D. Schendel, Shirley D. Johnston
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Intracellular spatiotemporal metabolism in connection to target engagement

Advanced Drug Delivery Reviews, 2023
The metabolism in eukaryotic cells is a highly ordered system involving various cellular compartments, which fluctuates based on physiological rhythms. Organelles, as the smallest independent sub-cell unit, are important contributors to cell metabolism and drug metabolism, collectively designated intracellular metabolism.
Jingwei, Zhang, Zhixia, Qiu, Yongjie, Zhang, Guangji, Wang, Haiping, Hao   +4 more
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Target engagement and histopathology of neuraxial resiniferatoxin in dog

Veterinary Anaesthesia and Analgesia, 2018
To evaluate target engagement of intracisternally (IC) delivered TRPV1 agonist, resiniferatoxin (RTX), as measured by primary afferent and dorsal horn substance P immunoreactivity (sP-IR), histopathology and thermal escape latencies in dogs.Prospective experimental trial.Fourteen adult male Beagle dogs, weighing 10.3-13.2 kg; 11 dogs surviving to ...
Tyler M, Hockman, Alvaro F, Cisternas, Bryan, Jones, Mark T, Butt, Kent G, Osborn, Joanne J, Steinauer, Shelle A, Malkmus, Tony L, Yaksh   +7 more
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Rules of Engagement and Targeting

2015
This chapter discusses the interaction between targeting (including applicable law) and the rules of engagement (ROE) for international operations. It begins with an examination of the nature, composition, and purpose of ROE in general. This includes the legal, policy, and military operational aspects of ROE, as well as their effect on ROE composition ...
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Simplified Target Assignment Problem for Group Engagement of Aircraft

Automation and Remote Control, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
V. I. Merkulov, A. S. Plyashechnik
openaire   +2 more sources