Results 231 to 240 of about 321,890 (254)

Pharmacological Target Engagement and Validation

2022
openaire   +1 more source

Quantitative Kinase Target Engagement

Genetic Engineering & Biotechnology News, 2018
Kristin Huwiler, James Vasta, Cesear Corona, Chad Zimprich, Jennifer Wilkinson, Morgan Ingold, Matthew Robers   +6 more
openaire   +1 more source

Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery

SLAS Discovery, 2021
Jeremy Presland, Jongwon Lim, Ilona Kariv   +2 more
exaly  

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

ChemBioChem, 2021
Kilian Huber, Jennifer A Ward, Jeffrey Martin   +2 more
exaly  

Target Engagement and Pharmacotherapy in Eating Disorders

Abstract While eating disorders are severe psychiatric disorders, effective pharmacological therapies are largely lacking. To date, only two medications have been approved for the treatment of eating disorders: fluoxetine for bulimia nervosa and lisdexamfetamine for binge-eating disorder.
openaire   +1 more source

Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery

SLAS Discovery, 2021
Kevin Dalby, Eun Jeong Cho
exaly  

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Annual Review of Pharmacology and Toxicology, 2016
Par Nordlund, Daniel Martinez Molina
exaly  

Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

SLAS Discovery, 2020
Luke A Greenhough, Mahnoor Mahmood, Simon Lucas   +2 more
exaly  

ENHANCEMENT OF KINASE TARGET ENGAGEMENT

2021
VASTA JAMES, ROBERS MATTHEW
openaire   +3 more sources

High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms

SLAS Discovery, 2020
Brian Sparling, Antony Symons
exaly