Results 231 to 240 of about 2,773,596 (266)

Targeted Fluorescent Probes in Peroxisome Function

The Histochemical Journal, 2001
Fluorescent peptides form a new generation of analytical tools for visualizing intracellular processes and molecular interactions at the level of single cells. The peptide-based reporters combine the sensitivity of fluorescence detection with the information specificity of amino acid sequences.
Dansen, T. B., Pap, E. H. W., Wanders, R. J., Wirtz, K. W.   +3 more
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Targeting the sarcomere to correct muscle function

Nature Reviews Drug Discovery, 2015
Various human diseases can disrupt the balance between muscle contraction and relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by intervening in signalling pathways or directly through interaction with the muscle proteins that control contraction.
Peter M, Hwang, Brian D, Sykes
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Targeting the Abnormalities of Gastroduodenal Functions in Functional Dyspepsia

Digestive Diseases, 2001
The current definition of functional dyspepsia changes the previous concept of absence of organic disease to the presence of a functional alteration of the upper gastrointestinal tract. From a theoretical point of view, the alteration of any major gastrointestinal function may induce dyspeptic symptoms.
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Therapeutic targeting of osteoclast function and pathways

Expert Opinion on Therapeutic Targets, 2011
Osteoclasts are responsible for bone resorption and underlie a number of pathological states in which osteolysis is a feature. Over recent decades our molecular understanding of osteoclast differentiation and activation has expanded significantly, and this has allowed for the development of a number of osteoclast-targeted therapies.This review seeks to
Broadhead, Matthew L, Clark, Jonathan C. M, Dass, Crispin R, Choong, Peter F. M, Myers, Damian E   +4 more
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Targeted and Functional Imaging

2008
The emerging field of targeted therapy is ushering in a new era of targeted/functional imaging, which compliments and sometimes improves upon traditional anatomic imaging for diagnosis, early assessment of treatment response, and estimation of durability of therapeutic success.
Vikas Kundra, Dawid Schellingerhout, Edward F. Jackson   +2 more
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Mitochondrial function in cardiomyocytes: target for cardioprotection

Current Opinion in Anaesthesiology, 2005
Cardiac diseases including ischemic heart disease, cardiomyopathy, hypertension, atherosclerosis and congestive heart failure are associated with cardiac cell death as a result of both necrosis and apoptosis. Mitochondria play an essential role in deciding whether a cell lives or dies. This review summarizes current knowledge on the mechanisms by which
Dipak K, Das, Nilanjana, Maulik
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Biotin-functionalized targeted polydiacetylene micelles

Chemical Communications, 2018
Polydiacetylene micelles were functionalized with controlled amounts of biotin using bioorthogonal click chemistry.
Doerflinger, Anaëlle, Quang, Nam Nguyen, Gravel, Edmond, Pinna, Guillaume, Vandamme, Marie, Duconge, Frederic, Doris, Eric   +6 more
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Functional genomics to new drug targets

Nature Reviews Drug Discovery, 2004
The completion of the sequencing of the human genome, and those of other organisms, is expected to lead to many potential new drug targets in various diseases, and it is predicted that novel therapeutic agents will be developed against such targets. The role of functional genomics in modern drug discovery is to prioritize these targets and to translate
Richard, Kramer, Dalia, Cohen
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TARGET COSTING FUNCTIONS [PDF]

Revista Economica, 2015
This article aims to highlight the concept of Target Costing. Based on the characteristics of Target Costing, identified in specialized literature, the article presents its main advantages and disadvantages. Also, a comparison is being made between Target Cost and Traditional Cost (in its traditional form, the cost represents an independent variable on
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FK506, An Immunosuppressant Targeting Calcineurin Function

Current Medicinal Chemistry, 2000
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption of signaling events mediated by the calcium-dependent serine threonine protein phosphatase, calcineurin (CaN), in T lymphocytes.
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