Results 1 to 10 of about 21,971 (136)

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma [PDF]

Communications Biology, 2022
Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.
Kavita Praveen, Gaurang C. Patel, Lauren Gurski, Ariane H. Ayer, Trikaladarshi Persaud, Matthew D. Still, Lawrence Miloscio, Tavé Van Zyl, Silvio Alessandro Di Gioia, Ben Brumpton, Kristi Krebs, Bjørn Olav Åsvold, Esteban Chen, Venkata R. M. Chavali, Wen Fury, Harini V. Gudiseva, Sarah Hyde, Eric Jorgenson, Stephanie Lefebvre, Dadong Li, Alexander Li, James Mclninch, Brijeshkumar Patel, Jeremy S. Rabinowitz, Rebecca Salowe, Claudia Schurmann, Anne-Sofie Seidelin, Eli Stahl, Dylan Sun, Tanya M. Teslovich, Anne Tybjærg-Hansen, Cristen Willer, Scott Waldron, Sabrina Walley, Hua Yang, Sarthak Zaveri, Regeneron Genetics Center, GHS-RGC DiscovEHR Collaboration, Estonian Biobank Research Team, Ying Hu, Kristian Hveem, Olle Melander, Lili Milani, Stefan Stender, Joan M. O’Brien, Marcus B. Jones, Gonçalo R. Abecasis, Michael N. Cantor, Jonathan Weyne, Katia Karalis, Aris Economides, Giusy Della Gatta, Manuel A. Ferreira, George D. Yancopoulos, Aris Baras, Carmelo Romano, Giovanni Coppola   +56 more
doaj   +4 more sources

Evaluating target intraocular pressures in primary congenital glaucoma

Indian Journal of Ophthalmology, 2021
Purpose: The aim of this study was to evaluate long-term intraocular pressures that provide stabilization/reversal of glaucomatous neuropathy after surgery in primary congenital glaucoma (PCG).
Ramanjit Sihota, Talvir Sidhu, Rinky Agarwal, Ajay Sharma, Amisha Gupta, Anin Sethi, Tanuj Dada, Veena Pandey   +7 more
doaj   +3 more sources

The Effect of Achieving Target Intraocular Pressure on Visual Field Worsening. [PDF]

Ophthalmology, 2022
To estimate the effect of achieving target intraocular pressure (IOP) values on visual field (VF) worsening in a treated clinical population.Retrospective analysis of longitudinal data.A total of 2852 eyes of 1688 patients with glaucoma-related diagnoses treated in a tertiary care practice.
Villasana GA, Bradley C, Ramulu P, Unberath M, Yohannan J.   +4 more
europepmc   +3 more sources

Evaluation of the Benefits of a Pharmacist-led Educational Program on Achievement of Intra-ocular Pressure Target among Patients with Open Angle Glaucoma: A Qusai-experimental Study [PDF]

Journal of Research in Pharmacy Practice
Objectives: To evaluate the effectiveness of a pharmacist-led educational program in achieving intraocular pressure (IOP) target, as well as in improving adherence and proficiency in eye drop administration techniques among glaucoma patients.
Duaa Raad Sadiq, Ehab Mudher Mikhael, Ameer Maarouf Mansour   +2 more
doaj   +2 more sources

Simplifying “target” intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma [PDF]

Indian Journal of Ophthalmology, 2018
Lowering of intraocular pressure is currently the only therapeutic measure for Glaucoma management. Many longterm, randomized trials have shown the efficacy of lowering IOP, either by a percentage of baseline, or to a specified level.
Ramanjit Sihota, Dewang Angmo, Deepa Ramaswamy, Tanuj Dada   +3 more
doaj   +2 more sources

Personalized Prediction of Glaucoma Progression Under Different Target Intraocular Pressure Levels Using Filtered Forecasting Methods. [PDF]

Ophthalmology, 2018
To generate personalized forecasts of how patients with open-angle glaucoma (OAG) experience disease progression at different intraocular pressure (IOP) levels to aid clinicians with setting personalized target IOPs.Secondary analyses using longitudinal data from 2 randomized controlled trials.Participants with moderate or advanced OAG from the ...
Kazemian P, Lavieri MS, Van Oyen MP, Andrews C, Stein JD.   +4 more
europepmc   +4 more sources

Optical coherence tomography (OCT) changes after achieving target intraocular pressure

Delta Journal of Ophthalmology, 2017
Purpose The aim of this study was to evaluate the ability of optical coherence tomography (OCT) to detect the changes in retinal nerve fiber layer (RNFL) after reaching target intraocular pressure (IOP) in glaucomatous patients.
Mohamed Y.S Saif, Mohamed O Abd Elkhalek, Moustafa M Tawfeek   +2 more
doaj   +2 more sources

Intraocular pressure is a promising target for myopia control

Journal of Translational Medicine
Background Myopia presents a noteworthy global health concern, urging exploration of innovative treatments. The role of intraocular pressure (IOP) in regulating the progression of myopia has been controversial.
Peiyuan Wang, Kangjie Kong, Jiaxuan Jiang, Jingwen Jiang, Zihong Xie, Fengbin Lin, Yunhe Song, Xiuli Fang, Ling Jin, Fei Li, Wei Wang, Shaolin Du, Zhuoxing Shi, Junwen Zeng, Xiulan Zhang, Shida Chen, for the Glaucoma Suspects with High Myopia Study Group   +16 more
doaj   +2 more sources

Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure.

PLoS ONE, 2012
Primary open-angle glaucoma is the second leading cause of blindness in the United States and is commonly associated with elevated intraocular pressure (IOP) resulting from diminished aqueous humor (AH) drainage through the trabecular pathway. Developing
Padma Iyer, Robert Lalane, Corey Morris, Pratap Challa, Robin Vann, Ponugoti Vasantha Rao   +5 more
doaj   +3 more sources

Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2022
Introduction/Objective. Pseudoexfoliation syndrome is characterized by abnormal production and accumulation of fibrillar, white-gray, “dandruff-like” material in almost all ocular structures. The aim of this study was to examine effect of selective laser
Kontić Marko, Todorović Dušan, Zečević Rada, Šarenac-Vulović Tatjana   +3 more
doaj   +1 more source