Results 91 to 100 of about 22,090 (255)

Practical approach to medical management of glaucoma

Indian Journal of Ophthalmology, 2008
Primary open angle glaucoma (POAG) is usually a chronic, slowly progressive disease. At present, all resources are directed towards reduction of intraocular pressure (IOP), the only known causal and treatable risk factor for glaucoma, and medical ...
Parikh Rajul, Parikh Shefali, Navin Shoba, Arun Ellen, Thomas Ravi   +4 more
doaj  

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Micropulse cyclophotocoagulation in the treatment of primary open-angle glaucoma and congenital glaucoma. Part 1: hypotensive effect mechanisms, modern procedure protocol

Российский офтальмологический журнал
Micropulse cyclophotocoagulation (MP-CPC) refers to interventions that reduce intraocular pressure by laser exposure on the ciliary body, while the term “coagulation” in its name does not reflect the essence of the procedure, but is inherited from the ...
O. V. Ermakova, E. A. Ragozina
doaj   +1 more source

Topiramate‐induced acute angle closure with suprachoroidal effusion: Insights from a novel ultra‐wide‐field OCT device

Acta Ophthalmologica, EarlyView.
Michael Hafner, Nicolas Pensel, Nicolas C. D. Scherer, Marc J. Mackert, Siegfried G. Priglinger, Leonie F. Keidel, Maximilian J. Gerhardt   +6 more
wiley   +1 more source

Non‐physician delivered intravitreal injection service: A systematic review of safety, implementation, training and patient experience

Acta Ophthalmologica, EarlyView.
Abstract The global demand for intravitreal anti‐vascular endothelial growth factor (anti‐VEGF) therapy continues to rise, straining ophthalmic capacity worldwide. Task shifting from physicians to trained non‐physician healthcare professionals has emerged as a potential strategy to expand service delivery.
Trang Truong Laursen, Haris Bralic, Jakob Grauslund, Yousif Subhi, Lonny Stokholm   +4 more
wiley   +1 more source

Macrophage-induced integrin signaling promotes Schlemm’s canal formation to prevent intraocular hypertension and glaucomatous optic neuropathy

Cell Reports
Summary: Schlemm’s canal (SC) functions to maintain proper intraocular pressure (IOP) by draining aqueous humor and has emerged as a promising therapeutic target for glaucoma, the second-leading cause of irreversible blindness worldwide.
Xinyu Gu, Xun Chen, Xuan Zhang, Keli Liu, Jing-Jing Li, Wenyu Lv, Lei Zeng, Mingjuan Wu, Weibin Zhou, Weifa Wang, Shunhua Shi, Yicheng Deng, Yunhua Li, Xinbo Gao, Rong Ju, Alexandre Dubrac, Xialin Liu, Feng Zhang   +17 more
doaj   +1 more source

Prenatal and childhood exposure to smoking and retinal nerve fibre layer thickness: A meta‐analysis of three independent birth cohorts

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine retinal nerve fibre layer (RNFL) characteristics in relation to prenatal and postnatal smoking exposure in three independent birth cohorts: two Danish and one Australian cohort. Methods A combined meta‐analysis of peripapillary retinal nerve fibre thickness in the Copenhagen Prospective Studies on Asthma in Childhood 2000 ...
Linna Zhu, Inger Christine Munch, Samantha Sze‐Yee Lee, David A. Mackey, Tamo Sultan, Klaus Bønnelykke, Bo Chawes, Michael Larsen, Nicklas Brustad   +8 more
wiley   +1 more source

The efficacy and safety of reducing intraocular pressure to single‐digit levels in Normal‐tension glaucoma: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose This systematic review and meta‐analysis aim to evaluate the efficacy and safety of further lowering intraocular pressure (IOP) to single‐digit levels in treated patients with progressive normal‐tension glaucoma (NTG). Methods A literature search was conducted in MEDLINE (via PubMed), Scopus and Web of Science. We selected studies that
Beatriz Araújo‐Azevedo, Renato Ferreira‐da‐Silva, João Barbosa‐Breda   +2 more
wiley   +1 more source

Establishing target intraocular pressure in newly diagnosed exfoliation glaucoma patients

Expert Review of Ophthalmology
This study aimed to determine the appropriate target intraocular pressure (IOP) for patients newly diagnosed with exfoliation glaucoma. The study followed a prospective cohort of newly diagnosed exfoliation patients for three years. The target IOP was defined using three methods to measure visual field deterioration, mean deviation (MD), visual field ...
openaire   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source