Results 71 to 80 of about 2,186,957 (289)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Perceptions of Language Learners across Various Proficiency Levels of Teachers’ Code-switching [PDF]

open access: yesIssues in Language Teaching, 2016
Code-switching (CS), an alternation between two or more languages or language varieties, has long been researched in language education. A great number of studies by applied linguists have explored the reasons for, and the potential usages of code ...
Abbas Ali Rezaee, Sajjad Fathi
doaj   +1 more source

Cross-Lingual Dependency Parsing for Closely Related Languages - Helsinki's Submission to VarDial 2017

open access: yes, 2017
This paper describes the submission from the University of Helsinki to the shared task on cross-lingual dependency parsing at VarDial 2017. We present work on annotation projection and treebank translation that gave good results for all three target ...
Tiedemann, Jörg
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Language Transfer of Audio Word2Vec: Learning Audio Segment Representations without Target Language Data

open access: yes, 2017
Audio Word2Vec offers vector representations of fixed dimensionality for variable-length audio segments using Sequence-to-sequence Autoencoder (SA).
Lee, Hung-Yi   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Phonological, Morphological and Syntactical Influences of Mother Tongue on Arab Learners

open access: yesEnglish Review: Journal of English Education, 2015
Arab learners' mother tongue influence on target language (English) is a very usual and well-known phenomenon in schools and universities. The present study attempts to find and analyze phonological, morphological and syntactical influences of mother ...
Taj Mohammad
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

The Targeting System of Language [PDF]

open access: yesFrontiers in Psychology, 2018
A linguistic/cognitive system of “targeting” is proposed that unifies the traditionally distinct domains of anaphora and deixis. As a speaker communicates with a hearer, her attention can come to be on something in the environment — her “target” — that she wants the hearer's attention to be on as well at a certain point in her discourse.
openaire   +4 more sources

Hedef Kültürde Doğru İletişim İçin Uygun Kelime Edinimi

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2009
Dilbilgisi-çeviri yönteminden iletişimsel yaklaşıma kadar olan dil öğretim metotlarısürecinde her metot, bir önceki metotta tespit ettiği eksiklikleri gidermek iddiasıyla ortaya çıkmıştır. Seksenli yıllarda ise iletişimsel yaklaşımla birlikte, yabancıdil
Hasan Yılmaz
doaj  

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