Results 221 to 230 of about 6,718,347 (301)

Preliminary Field-Note Observations on Referral Uptake Among Community-Dwelling Older Adults: A Qualitative Pilot Study in Tarrant County, Texas. [PDF]

Health Serv Insights
Sease A, Alexander G, Posey K, Gentea F, Olabisi E, Drenowatz B, Knight K.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Designing eligibility and evaluation criteria for antibacterial pull incentives: a comparative review of implemented and emerging initiatives. [PDF]

Lancet Reg Health Eur
Anderson M, O'Neill E, Ljungqvist G, Cherla A, Claessens Z, Schoefs E, Crabb N, Cowell W, Cohn J, Patel D, Mossialos E.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Parent-Facing Decision Aid About Childhood Vaccination: Co-development Study Adapting a Shared Decision-Making Approach to Support Evidence-Guided Decision-Making. [PDF]

J Particip Med
Bussink-Voorend D, Vandeberg L, Hautvast J, Elwyn G, Hulscher ME.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Communication successes, challenges, and needs among extension and outreach professionals engaging small-scale and non-intensive swine farmers. [PDF]

Front Vet Sci
Struck M, Schultze ML, Beckford G, Pradhananga AK, Perez AM, Schambow RA.   +5 more
europepmc   +1 more source

The social context of transition and rehabilitation

, 2018
Adair-Stantiall, A., Needs, Adrian
core  

Interactions between self-help and hospice and palliative care - Opportunities, barriers and needs (Self-Pall): A study protocol. [PDF]

PLoS One
Kauzner S, Schneider M, Berendt J, Ostgathe C, Heckel M.   +4 more
europepmc   +1 more source