Results 101 to 110 of about 281,007 (291)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study

Blood Pressure, 2019
Purpose: Smoking was identified as a potential factor contributing to fibromuscular dysplasia (FMD). To evaluate the prevalence of smoking and clinical characteristics in FMD subjects.
Piotr Dobrowolski, Magdalena Januszewicz, Helena Witowicz, Ewa Warchoł-Celińska, Anna Klisiewicz, Urszula Skrzypczyńska-Banasik, Marek Kabat, Katarzyna Kowalczyk, Anna Aniszczuk-Hybiak, Elżbieta Florczak, Adam Witkowski, Andrzej Tykarski, Krystyna Widecka, Małgorzata Szczerbo-Trojanowska, Witold Śmigielski, Wojciech Drygas, Ilona Michałowska, Piotr Hoffman, Aleksander Prejbisz, Andrzej Januszewicz   +19 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

MOESM1 of Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans [PDF]

, 2019
Additional file 1: Table S1. Regression results for the association between epigenetic age acceleration and blood pressure in GENOA African Americans (n = 1390). Table S2.
Sharon Kardia (3503060), Stephen Turner (3503027), Jeremy Raisky (7532981), Thomas Mosley (115371), Wei Zhao (14321), Scott Ratliff (7532984), Jiaxuan Liu (5185280), Jennifer Smith (172056)   +7 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa [PDF]

, 1998
Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic.
Petit, Claude, Embvani, E., Jaeg, Jean-Philippe, Tardieu, Didier, Corpet, Denis E., Cadet, Jean   +5 more
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Blood pressure monitoring in kidney transplantation: a systematic review on hypertension and target organ damage [PDF]

, 2021
Background. Few studies show that ambulatory blood pressure (BP) monitoring (ABPM) is superior to office BP (oBP) measurements to predict target organ damage and cardiovascular (CV) events in kidney transplant recipients (KTRs). We performed a systematic
Bolignano, Davide, Halimi, Jean-Michel, Sautenet, Benedicte, Rossignol, Patrick, Vogt, Liffert, D'Arrigo, Graziella, Sarafidis, Pantelis, Zoccali, Carmine, Loutradis, Charalampos, Persu, Alexandre, Ferro, Charles J., London, Gerard, Michel, Pisano, Anna, Kanaan, Nada, Boletis, Ioannis N., Mallamaci, Francesca, Burnier, Ortiz, Alberto, Wuerzner, Gregoire   +19 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source