Results 91 to 100 of about 569,729 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Systemic Problems: A perspective on stem cell aging and rejuvenation. [PDF]

, 2015
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies.
CONBOY, Irina M, Conboy, Michael, Rebo, Justin   +2 more
core   +2 more sources

Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study

Clinical Interventions in Aging, 2021
Song Zhao, Zhongyuan Ren, Shikai Yu, Chen Chi, Jiamin Tang, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Jiaxin Li, Yawei Xu, Yi Zhang Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072,
Zhao S, Ren Z, Yu S, Chi C, Tang J, Maimaitiaili R, Teliewubai J, Li J, Xu Y, Zhang Y   +9 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus [PDF]

, 2019
Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is ...
Barbato, Emanuele, Bartunek, Jozef, Colaiori, Iginio, de Simone, Giovanni, Di Gioia, Giuseppe, Franco, Danilo, Izzo, Raffaele, Losi, Maria Angela, Mancusi, Costantino, Manzi, Maria Virginia, Morisco, Carmine, Rapacciuolo, Antonio, Strisciuglio, Teresa, Trimarco, Bruno   +13 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Association Between Healthy and Non-healthy Vascular Aging with Hypertensive Target Organ Damage in Hospitalized Patients

Artery Research
Objective To investigate the correlation between healthy vascular aging (HVA) and non-healthy vascular aging (NHVA) with hypertensive target organ damage (TOD).
Huijuan Chao, Qian Wang, Yanqing Bao, Yaya Bai, Mark Butlin, Alberto Avolio, Junli Zuo   +6 more
doaj   +1 more source

Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study

Blood Pressure, 2019
Purpose: Smoking was identified as a potential factor contributing to fibromuscular dysplasia (FMD). To evaluate the prevalence of smoking and clinical characteristics in FMD subjects.
Piotr Dobrowolski, Magdalena Januszewicz, Helena Witowicz, Ewa Warchoł-Celińska, Anna Klisiewicz, Urszula Skrzypczyńska-Banasik, Marek Kabat, Katarzyna Kowalczyk, Anna Aniszczuk-Hybiak, Elżbieta Florczak, Adam Witkowski, Andrzej Tykarski, Krystyna Widecka, Małgorzata Szczerbo-Trojanowska, Witold Śmigielski, Wojciech Drygas, Ilona Michałowska, Piotr Hoffman, Aleksander Prejbisz, Andrzej Januszewicz   +19 more
doaj   +1 more source

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

Biology of Sex Differences, 2020
Hypertension (HTN) is a primary risk factor for cardiovascular (CV) events, target organ damage (TOD), premature death and disability worldwide. The pathophysiology of HTN is complex and influenced by many factors including biological sex.
Andrea Rodrigues Sabbatini, Georgios Kararigas   +1 more
doaj   +1 more source