Results 71 to 80 of about 281,007 (291)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage
Journal of Aging Research, 2011 Chronic hypertension leads to concomitant remodeling of the cardiac and vascular systems and various organs, especially the brain, kidney, and retina. The brain is an early target of organ damage due to high blood pressure, which is the major modifiable ...
Cristina Sierra +2 more
doaj +1 more source
BMC Medical Genomics, 2019 Background Epigenetic age acceleration, a measure of biological aging based on DNA methylation, is associated with cardiovascular mortality. However, little is known about its relationship with hypertensive target organ damage to the heart, kidneys ...
Jennifer A. Smith +7 more
doaj +1 more source
Target organ damage in black hypertensives. [PDF]
Circulation, 1977 A representative sample of black hypertensives has been appraised to determine candidacy for hypertension treatment. A total of 1759 black residents were successfully screened at home. Forty-one percent of the males and 33% of the females had diastolic blood pressures of 95 mm Hg or greater.
G, Entwisle +3 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Excess aldosterone as a mechanism of resistant salt-sensitive arterial hypertension [PDF]
, 2022 Albeit vastly underdiagnosed, primary aldosteronism is the most common cause of arterial hypertension and particularly of drug-resistant arterial hypertension, a high-risk condition with a poor prognosis. A timely diagnosis followed by targeted treatment
Torresan, Francesca
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Diagnosis and Management of Resistant Hypertension:A Case Report [PDF]
, 2019 We described the diagnostic workup and management of an obese patient with resistant hypertension, who was hospitalized for heart failure. The case was complicated by comorbidities such as diabetes mellitus.
Vamsi, Varahabhatla +15 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source