Results 61 to 70 of about 276,174 (253)

Risk reclassification in patients first contacting a doctor with uncomplicated hypertension

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the changes of SCORE cardiovascular risk (CVR) in patients with hypertension (HTN) who first seek medical help taking into account target organ damage (TOD).Material and methods.
T. V. Kamyshova, A. A. Sarycheva, V. D. Sargsyan, A. S. Safaryan, D. V. Nebieridze   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study

Clinical Interventions in Aging, 2021
Song Zhao, Zhongyuan Ren, Shikai Yu, Chen Chi, Jiamin Tang, Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Jiaxin Li, Yawei Xu, Yi Zhang Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072,
Zhao S, Ren Z, Yu S, Chi C, Tang J, Maimaitiaili R, Teliewubai J, Li J, Xu Y, Zhang Y   +9 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Strain of Detecting Early Target Organ Damage in Hypertension

Journal of the American College of Cardiology, 2015
Hypertension contributes substantially to the burden of disease in developed nations and, increasingly, in the developing world [(1)][1]. Although recognition of high blood pressure (BP) seems simple, 20% to 30% of individuals have undiagnosed hypertension [(2)][2], and 50% to 70% of ...
Marwick, Thomas H., Venn, Alison J.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Association Between Healthy and Non-healthy Vascular Aging with Hypertensive Target Organ Damage in Hospitalized Patients

Artery Research
Objective To investigate the correlation between healthy vascular aging (HVA) and non-healthy vascular aging (NHVA) with hypertensive target organ damage (TOD).
Huijuan Chao, Qian Wang, Yanqing Bao, Yaya Bai, Mark Butlin, Alberto Avolio, Junli Zuo   +6 more
doaj   +1 more source