Results 61 to 70 of about 281,007 (291)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Target organ damage in canine and feline systemic hypertension: a review [PDF]

, 2022
Hypertension is a state of persistent elevation of arterial blood pressure and a major risk factor for cardiovascular diseases. Chronic exposure to blood pressure results in target organs damage (TOD).
Adejumobi , O.A., Oyagbemi , A. A., Omobowale , T.O., Ajibade , T.O., Adedapo , A.A., Nottidge , H. O.   +5 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ambulatory arterial stiffness indices and target organ damage in hypertension

BMC Cardiovascular Disorders, 2012
Background The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and renal damage in hypertensive individuals.
Gómez-Marcos Manuel, Recio-Rodríguez José, Patino-Alonso Ma, Gómez-Sánchez Leticia, Agudo-Conde Cristina, Gómez-Sánchez Marta, Rodríguez-Sánchez Emiliano, García-Ortiz Luís   +7 more
doaj   +1 more source

Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism

Frontiers in Cardiovascular Medicine, 2022
Primary aldosteronism (PA) is the most common type of endocrine hypertension, and numerous experimental and clinical evidence have verified that prolonged exposure to excess aldosterone is responsible for an increased risk of cerebro-cardiovascular ...
Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan, Jun Liu, Jun Liu, Jun Liu   +9 more
doaj   +1 more source

Should Target Organ Damage Become a Therapeutic Target?

The Journal of Clinical Hypertension, 2013
In this issue of the Journal, Shlomai, Grassi, Grossman,and Mancia address the always “hot topic” of targetorgan damage in patients with hypertension in an articleentitled “Assessment of Target Organ Damage in theEvaluation and Follow-Up of the Hypertensive Patients:Where Do We Stand?” The article is thoughtful andinformative, considers the facts and ...
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Target organ damage in stress-induced arterial hypertension

Кардиоваскулярная терапия и профилактика, 2009
Aim. То investigate the features of target organ damage in patients with stress-induced arterial hypertension (AH).Material and methods. The study included 329 men, aged 29—55 years, with Stage I-II AH. Group I consisted of 197 individuals with workplace
O. N. Antropova, I. V. Osipova, N. А. Lobanova, K. I. Shakhmatova   +3 more
doaj  

P55 TARGET ORGAN DAMAGE AND BLOOD PRESSURE VARIABILITY IN HYPERTENSION

Artery Research, 2017
Purpose/Background/Objectives: Hypertension is associated with several markers of subclinical target organ damage (TOD). Short-term blood pressure variability (SBPV) is a prognostic factor for cardiovascular events in hypertensives.
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Angelis, Nikolaos Loakeimidis, Panagiotis Xaplanteris, Christos Georgakopoulos, Evangelia Sigala, Losif Koutagiar, Angeliki Rigatou, Dimitrios Tousoulis   +9 more
doaj   +1 more source

Sense of coherence and hypertensive target organ damage

Psychiatria Polska, 2019
Cel pracyNadciśnienie tętnicze może być powikłane uszkodzeniami narządowymi (oznaczanymi w języku angielskim skrótem TOD – target organ damage). Do chwili obecnej udało się zidentyfikować wiele różnych czynników powiązanych z rozwojem TOD. Jednak, zgodnie z naszą wiedzą, nie próbowano wyodrębnić zmiennych psychologicznych, które różnicują pacjentów z ...
Lech, Popiołek, Iwona, Gawlik, Olga, Siga, Anna, Dzieża-Grudnik, Małgorzata, Moląg, Paweł, Rodziński, Tomasz, Grodzicki, Jolanta, Walczewska, Krzysztof, Rutkowski   +8 more
openaire   +2 more sources