Results 81 to 90 of about 569,729 (301)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
Baroreflex deficit are associated with target organ damage
O Mundo da Saúde, 2017 RETRACTED The editorial team of the Journal O Mundo da Saúde communicates the formal retracted the article: PAULINI, Janaina. Baroreflex deficit are associated with target organ damage. Rev. O Mundo da Saúde. 2017;40, n. A: 433-46. https://doi.org/
Janaina Paulini
doaj
Risk reclassification in patients first contacting a doctor with uncomplicated hypertension
Кардиоваскулярная терапия и профилактика, 2019 Aim. To assess the changes of SCORE cardiovascular risk (CVR) in patients with hypertension (HTN) who first seek medical help taking into account target organ damage (TOD).Material and methods.
T. V. Kamyshova +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Serum uric acid and target organ damage in essential hypertension
Vascular Health and Risk Management, 2014 Sandra N Ofori, Osaretin J OdiaDepartment of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, NigeriaBackground: Hypertension is a major risk factor for cardiovascular mortality, as it acts through its ...
Ofori SN, Odia OJ
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Konseling Hipertensi dan Komplikasinya pada Lansia di Kelurahan Tosaren RT 28 RW 10 [PDF]
, 2018 Hypertension is a state of increased blood pressure that gives symptoms to a target organ resulting in damage as a stroke (occurs in the organ and effects the high mortality). Coronary heart disease (damage to the blood vessels of the heart).
Astika Sari, Nita Dwi +5 more
core
The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]
, 2016 PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela +2 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source