Results 81 to 90 of about 281,007 (291)

Blood pressure related to age:The India ABPM study [PDF]

, 2019
The present paper reports trends in office blood pressure (BP) measurement (OBPM) and ambulatory blood pressure measurement (ABPM) with age in a large multi-center Indian all comers' population visiting primary care physicians. ABPM and OBPM data from 27
Suvarna, Viraj, Sunil Kapoor, Kapoor, Sunil, Borges, Eric, Sharma, Kamal, Budanur C. Srinivas, Jitendra P. S. Swahney, Verberk, Willem J., Abraham Oomman, Hiremath, Jagdish, Upendra Kaul, Priyadarshini Arambam, Kamal Sharma, Srinivas, Budanur C., Oomman, Abraham, Chandrashekhar K. Ponde, Manoj Chopda, Eric Borges, Nair, Tiny, Viraj Suvarna, Kaul, Upendra, Tiny Nair, Willem J. Verberk, Rao, Srinivas, Jasuja, Sanjiv, Ponde, Chandrashekhar K., Swahney, Jitendra P. S., Arambam, Priyadarshini, Jagdish Hiremath, Omboni, Stefano, Sanjiv Jasuja, Chopda, Manoj, Stefano Omboni, Srinivas Rao   +33 more
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Vitamin D depletion aggravates hypertension and target-organ damage [PDF]

, 2015
BACKGROUND: We tested the controversial hypothesis that vitamin D depletion aggravates hypertension and target-organ damage by influencing renin. METHODS AND RESULTS: Four-week-old double-transgenic rats (dTGR) with excess angiotensin (Ang) II production
Jørgensen, Jan Stener, Poglitsch, M., Jørgensen, J.S., Gollasch, Maik, Sorensen, Grith Lykke; id_orcid, Poglitsch, Marko, Szijarto, István, Dechend, Ralf, Fruekilde, Palle, Qadri, F., Peters, Joerg, Przybyl, L., Muller, D.N., Gollasch, M., Qadri, Fatimunnisa, Haase, Nadine, Christesen, Henrik Thybo, Andersen, L.B., Peters, J., Christesen, H.T., Haase, N., Sorensen, G.L., Przybyl, Lukasz, Fruekilde, P., Andersen, Louise Bjørkholt, von Versen-Höynck, Frauke, von Versen-Höynck, F., Dechend, R., Szijártó, I., Muller, Dominik N   +29 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension [PDF]

, 2018
Hypertension is associated with cognitive deficits, probably caused by cerebral small vessel disease. The authors examined whether additional presence of cardiac and renal organ damages, and their combined presence, are associated with future cognitive ...
Kroon, Abraham A.; id_orcid, van Oostenbrugge, Robert J., Staals, Julie, van Kuijk, Sander M. J., Uiterwijk, Renske, de Leeuw, Peter W., Kroon, Abraham A., Huijts, Marjolein   +7 more
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Risk reclassification in patients first contacting a doctor with uncomplicated hypertension

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the changes of SCORE cardiovascular risk (CVR) in patients with hypertension (HTN) who first seek medical help taking into account target organ damage (TOD).Material and methods.
T. V. Kamyshova, A. A. Sarycheva, V. D. Sargsyan, A. S. Safaryan, D. V. Nebieridze   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes [PDF]

, 2019
ImportanceBlood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes.
Ibsen, H., Maestre, G., Wei, F. -F., Kuznetsova, T., Yang, W. -Y., Ohkubo, T., Casiglia, E., Li, Y., Thijs, Lutgarde, Wang, Ji-Guang, Kawecka-Jaszcz, K., Malyutina, Sofia, Sandoya, Edgardo, Boggia, Jose, Hansen, Tine W., Sheng, C. -S., Staessen, Jan A., Dolan, E., Thijs, L., Lind, Lars, Li, Yan, Filipovsky, J., Melgarejo, Jesus D., Filipovsky, Jan, Ticha, M., Narkiewicz, Krzysztof, Dolan, Eamon, Huang, Q. -F., Mujaj, B., Verhamme, Peter, Hansen, T. W., Torp-Pedersen, C., Asayama, Kei, Seidlerova, J., Jeppesen, J., Stolarz-Skrzypek, K., Imai, Yutaka, Jeppesen, Jorgen, O'Brien, Eoin, Cauwenberghs, N., Zhang, Z. -Y., Wang, J. -G., Yu, C. -G., Zhang, Zhen-Yu, Rasmussen, S., O'Brien, E.   +45 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Assessing strategies to target screening for advanced liver fibrosis among overweight and obese patients [PDF]

, 2022
Aim: The optimal screening strategy for advanced liver fibrosis in overweight and obese patients is unknown. The aim of this study is to compare the performance of different strategies to select patients at high risk of advanced liver fibrosis for ...
Bril, Fernando, Godinez Leiva, Eddison, Lomonaco, Romina, Gray, Meagan, Shrestha, Sulav, Kalavalapalli, Srilaxmi, Cusi, Kenneth   +6 more
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