Results 51 to 60 of about 5,291,171 (287)

SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Endoplasmic reticulum (ER) stress is an evolutionarily conserved adaptive response that contributes to deal with the misfolded or unfolded protein in the lumen of the ER and restore the ER homeostasis.
Fu-Quan Wang, S. Yao, Haifa Xia
semanticscholar   +1 more source

Study of microalbuminuria in essential hypertension patients with target organ damage [PDF]

, 2020
Background: Urinary albumin excretion has been purported to be strongly linked to cardiovascular events in hypertensive patients. The prevalence of microalbuminuria in patients with essential hypertension and its relationship with target organ damage was
Bakhtar, Vijay, Pandey, Kirit, Pandey, Neha, Bakhtar, Niyati   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The relationship of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension

BMC Cardiovascular Disorders, 2019
Background To investigate the relationships of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension.
Yang Liu, Yao Lin, Ming-Ming Zhang, T. Zheng, Xiao-Hui Li, Yanyan Liu, Jing Zhao, Lin Shi   +7 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Office blood pressure measurement in the 21st century

, 2018
Measurement of blood pressure (BP) using the auscultatory method must follow specific rules and conditions to be reliable. Nonetheless, these requirements are often not followed in clinical practice, resulting in inaccurate BP readings.
Staessen, Jan A., Myers, Martin G., Asmar, Roland   +2 more
core   +1 more source

Nocturnal dipping status and the association of morning blood pressure surge with subclinical target organ damage in untreated hypertensives

The Journal of Clinical Hypertension, 2019
The authors aimed to investigate the association between sleep‐through morning surge (MS) in blood pressure (BP) and subclinical target organ damage in untreated hypertensives with different nocturnal dipping status.
Shen-Zhen Gong, Kai Liu, Runyu Ye, Jiangbo Li, Changqiang Yang, Xiaoping Chen   +5 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Ambulatory arterial stiffness indices and target organ damage in hypertension

BMC Cardiovascular Disorders, 2012
Background The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and renal damage in hypertensive individuals.
Gómez-Marcos Manuel, Recio-Rodríguez José, Patino-Alonso Ma, Gómez-Sánchez Leticia, Agudo-Conde Cristina, Gómez-Sánchez Marta, Rodríguez-Sánchez Emiliano, García-Ortiz Luís   +7 more
doaj   +1 more source