Results 81 to 90 of about 1,479,995 (314)
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance [PDF]
Scientific Reports, 2015 AbstractEmergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance. Using in vitro drug screening, we identified 211 amino-acid substitutions conferring resistance to
Meenu Kesarwani +10 more
openaire +2 more sources
Investigation and characterisation of diamide insecticide resistance conferred by target-site mutations in the Ryanodine Receptor of lepidopteran pests [PDF]
, 2019 Lepidopteran crop pests such as Tuta absoluta, Chilo suppressalis, Spodoptera frugiperda and Plutella xylostella are becoming increasingly problematic, as populations colonise new regions of the globe.
Richardson, E.
core
bioRxiv, 2018 Resistance to pyrethroid insecticides is a major concern for malaria vector control, because these are the compounds used in almost all insecticide-treated bed-nets (ITNs), and are also widely used for indoor residual spraying (IRS).
Chris S. Clarkson +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Is hormesis an underestimated factor in the development of herbicide resistance?
Julius-Kühn-Archiv, 2014 The growing impact of herbicide resistant weeds increasingly affects weed management and the delay of resistance evolution has become a major task of chemical weed control.
Belz, Regina G.
doaj +1 more source
Agronomy, 2020 Corn poppy (Papaver rhoeas L.) and cornflower (Centaurea cyanus L.) are two overwintering weed species found in crop fields in Europe. They are characterised by a similar life cycle, similar competitive efforts, and a spectrum of herbicides recommended ...
Marta Stankiewicz-Kosyl +11 more
doaj +1 more source
Insecticide resistance resulting from an absence of target-site gene product [PDF]
Proceedings of the National Academy of Sciences, 1998 Genetic changes in insects that lead to insecticide resistance include point mutations and up-regulation/amplification of detoxification genes. Here, we report a third mechanism, resistance caused by an absence of gene product. Mutations of the Methoprene-tolerant ( Met ) gene of ...
T G, Wilson, M, Ashok
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Role of a novel I1781T mutation and other mechanisms in conferring resistance to acetyl-CoA carboxylase inhibiting herbicides in a black-grass population. [PDF]
PLoS ONE, 2013 BACKGROUND: Knowledge of the mechanisms of herbicide resistance is important for designing long term sustainable weed management strategies. Here, we have used an integrated biology and molecular approach to investigate the mechanisms of resistance to ...
Shiv Shankhar Kaundun +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source