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Progress, clinical application and challenges of non-invasive prenatal testing for monogenic diseases. [PDF]
Front PediatrWang C +7 more
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Diagnostic performance of gastrin-releasing peptide receptor-targeted positron-emission tomography in biochemically recurrent prostate cancer-a systematic review and meta-analysis. [PDF]
Quant Imaging Med SurgHuang H, Huang Y, Xie Z, Tian R, Shen G.
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Strategies for targeting undruggable targets
Expert Opinion on Drug Discovery, 2021Undruggable targets refer to clinically meaningful therapeutic targets that are 'difficult to drug' or 'yet to be drugged' via traditional approaches. Featuring characteristics of lacking defined ligand-binding pockets, non-catalytic protein-protein interaction functional modes and less-investigated 3D structures, these undruggable targets have been ...
Gong, Zhang +4 more
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Immunotherapy, 2010
745 ISSN 1750-743X Immunotherapy (2010) 2(6), 745–748 10.2217/IMT.10.66 © 2010 Future Medicine Ltd “Although it would be naive to conclude that biomarker programs are cheap and straightforward, it is likely to be a price worth paying in order to maximize the chance of success in the tortuous process of cancer drug development, and, ultimately, to ...
William, Shingler, Richard, Harrop
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745 ISSN 1750-743X Immunotherapy (2010) 2(6), 745–748 10.2217/IMT.10.66 © 2010 Future Medicine Ltd “Although it would be naive to conclude that biomarker programs are cheap and straightforward, it is likely to be a price worth paying in order to maximize the chance of success in the tortuous process of cancer drug development, and, ultimately, to ...
William, Shingler, Richard, Harrop
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Circulation Research, 2012
The intriguing biology of microRNAs, small regulatory noncoding RNA molecules encoded by the genome that coordinately regulate gene expression by targeting messenger RNAs, has opened new territories for our understanding of gene regulatory circuits in cardiac homeostasis and disease.
Paula A, Da Costa Martins +1 more
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The intriguing biology of microRNAs, small regulatory noncoding RNA molecules encoded by the genome that coordinately regulate gene expression by targeting messenger RNAs, has opened new territories for our understanding of gene regulatory circuits in cardiac homeostasis and disease.
Paula A, Da Costa Martins +1 more
openaire +2 more sources
2022
Abstract In this chapter we propose to treat metonymy as a cognitive operation of conceptual elaboration based on the part-whole relationship that is triggered by the use of an expression (or metonymic vehicle) associated with a certain conceptual cluster (or metonymic source) within a conceptual domain.
Mario Brdar, Rita Brdar-Szabó
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Abstract In this chapter we propose to treat metonymy as a cognitive operation of conceptual elaboration based on the part-whole relationship that is triggered by the use of an expression (or metonymic vehicle) associated with a certain conceptual cluster (or metonymic source) within a conceptual domain.
Mario Brdar, Rita Brdar-Szabó
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Targeting Intracellular Targets
Current Drug Delivery, 2004Many therapeutic agents have intracellular compartments as their site of action. Targeted delivery of these agents to their specific intracellular targets could result in enhanced therapeutic efficacy and reduced toxicity. Various carriers have been shown useful in targeted delivery of different classes of therapeutic agents.
Jayanth, Panyam, Vinod, Labhasetwar
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American Journal of Kidney Diseases, 2001
Using the vocabulary of ballistics in medicine for emphasis can result in misleading exaggeration and semantic confusion. The dual meaning of target as either aiming point (aim at) or outcome (aim to achieve) creates a muddle in the efforts to comply with quality assurance initiatives.
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Using the vocabulary of ballistics in medicine for emphasis can result in misleading exaggeration and semantic confusion. The dual meaning of target as either aiming point (aim at) or outcome (aim to achieve) creates a muddle in the efforts to comply with quality assurance initiatives.
openaire +2 more sources