Results 41 to 50 of about 3,752,482 (246)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review [PDF]

운동과학
PURPOSE Physical activity induces metabolic changes in the body. However, the biological mechanisms underlying these metabolic changes remain unclear. Metabolomics has advanced the field of exercise science, although most studies use invasive procedures ...
Zi-Xiao Yu, Ji-Suk Chang, Ah-Ram Kim, Ho-Seong Lee   +3 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Current Issues of Next-Generation Sequencing-Based Circulating Tumor DNA Analysis in Colorectal Cancer

South Asian Journal of Cancer
Evidence is mounting that circulating tumor deoxyribonucleic acid can be tested accurately, frequently, and in a noninvasive form. Its role in monitoring patients with cancer, particularly colorectal cancer, is increasing.
Narmadha Rathnasamy, Viraj Lavingia, Shyam Aggarwal, Vineet Talwar, Pragya Shukla, Nitesh Rohtagi, K. M. Prathasarathy, Deni Gupta, Rajesh Pasricha, Sunil Pasricha, R. K. Choudhary, Gautam Goyal, Saumitra Rawat, Purvish M. Parikh, C. Selvasekar   +14 more
doaj   +1 more source

Challenges of clinical trial design for targeted agents against pediatric leukemias

Frontiers in Oncology, 2015
The past 40 years have seen significant improvements in both event-free and overall survival for children with acute lymphoblastic or acute myeloid leukemia (ALL or AML respectively).
Francis Jay Mussai, Christina eYap, Pamela eKearns, Christopher eMitchell   +3 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Modelling Potential Candidates for Targeted Auger Therapy

Biophysica
Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue.
Conor M. J. Buchanan, Eric O. Aboagye, Lee J. Evitts, Michael J. D. Rushton, Tim A. D. Smith   +4 more
doaj   +1 more source

Tuberculin Skin Testing in Children

Emerging Infectious Diseases, 2006
In 1996, the American Academy of Pediatrics (AAP) recommended targeted tuberculin skin testing (TST) of children while discouraging routine TST of children without risk factors for tuberculosis (TB).
Marina Reznik, Philip O. Ozuah
doaj   +1 more source

Efficient Targeted Influence Maximization Based on Multidimensional Selection in Social Networks

Frontiers in Physics, 2021
The influence maximization problem over social networks has become a popular research problem, since it has many important practical applications such as online advertising, virtual market, and so on.
Dong Jing, Ting Liu
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source