Results 71 to 80 of about 3,752,482 (246)
Targeted therapies for vascular malformations
Frontiers in MedicineTargeted medical therapies for the treatment of vascular malformations is an exciting and evolving area of research. As the identification of specific causative genetic mutations involved in vascular malformations becomes more accessible and inexpensive,
Gavin Kane, Israel Fernandez-Pineda
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Targeted therapy for brain tumors: overview and application to precision medicine [PDF]
Exploration of NeuroscienceTargeted cancer therapies for cancer treatment are at the forefront of cancer treatments. The identification of pathologic cell signaling pathways in cancer cells via precision medicine enables the development of new therapies to target the underpinning ...
Herbert B. Newton, Beddome C. Allen
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, 2023 The present study shows a symmetric third-generation lung model by considering a specific position for targeted drug delivery (see Figure 30.1a). Left lung is chosen as the targeted region for the particle transport direction and deposition, as the left ...
Ghosh, A +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Targeted killing in humanitarian law [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2012 The “Targeted Killing” can be seen in various formsover the course of past history. It plans to explain the concept of "Targeted Killing under international law" as follows:First, it provides a legal and desirable definition of the concept;Second, it ...
Hossein Sartipi +2 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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Predicting the Persistence of Undeclared First-Year and Transfer Students
Journal of College Orientation, Transition, and Retention, 2015 A significant proportion of students enter four-year institutions without declaring an academic major, and institutions have developed targeted advising and services to help these students select careers and persist to graduation.
Sandra L. Dika +3 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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