Results 1 to 10 of about 727 (50)
Targeted alpha therapy for glioblastoma
Frontiers in Medicine, 2022 According to the 2021 World Health Organization Classification of Tumors of the Central Nervous System, glioblastoma (GB) is a primary brain tumor and presents with the worst prognosis. Due to its infiltrating characteristic, molecular heterogeneity, and
Jolanta Kunikowska +5 more
doaj +1 more source
Revisiting the Radiobiology of Targeted Alpha Therapy
Frontiers in Medicine, 2021 Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate cancer and the development of several alpha emitter-based ...
Jean-Pierre Pouget, Julie Constanzo
doaj +1 more source
Advances in Targeted Alpha Therapy: Preparation and Separation of Alpha Radionuclides
He huaxue yu fangshe huaxue, 2022 Targeted alpha therapy(TAT) is a promising approach for the treatment of cancer and it is under fast development in the past few decades. Owing to the high linear energy transfer(LET), short path length, high relative biological effect and cytotoxicity ...
WANG Lu-sheng +2 more
doaj +1 more source
Translational Oncology, 2022 The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA.
Thomas M. Jeitner +2 more
doaj +1 more source
Alpha‐emitters and targeted alpha therapy in cancer treatment
iRADIOLOGY, 2023 Alpha emitters are radionuclides with good pharmacological characteristics for the treatment of cancer because they decay by emitting high linear energy transfer particles.
Jiajia Zhang +5 more
doaj +1 more source
Pharmaceuticals, 2023 This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals.
Bryce J. B. Nelson +3 more
doaj +1 more source
Nanoparticles in Targeted Alpha Therapy
Nanomaterials, 2020 Recent advances in the field of nanotechnology application in nuclear medicine offer the promise of better therapeutic options. In recent years, increasing efforts have been made on developing nanoconstructs that can be used as carriers for immobilising ...
Agnieszka Majkowska-Pilip +4 more
doaj +1 more source
Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?
Frontiers in Medicine, 2022 Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation are locally delivered to tumor cells, while the surrounding healthy tissue is minimally affected.
Roger M. Pallares +2 more
doaj +1 more source
Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
Pharmaceutics, 2020 This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and ...
Bryce J. B. Nelson +2 more
doaj +1 more source
[212Pb]Pb-eSOMA-01: A Promising Radioligand for Targeted Alpha Therapy of Neuroendocrine Tumors
Pharmaceuticals, 2023 Peptide receptor radionuclide therapy (PRRT) has been applied to the treatment of neuroendocrine tumors (NETs) for over two decades. However, improvement is still needed, and targeted alpha therapy (TAT) with alpha emitters such as lead-212 (212Pb ...
Dylan Chapeau +11 more
doaj +1 more source