Results 31 to 40 of about 573,850 (267)
Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
doaj +1 more source
Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is
Fatemeh Sadeghi +5 more
doaj +1 more source
Preparation and Characterization of Undecylenoyl Phenylalanine Loaded-Nanostructure Lipid Carriers (NLCs) as a New α-MSH Antagonist and Antityrosinase Agent [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: The aim of this study was to characterize the undecylenoyl phenylalanine (Sepiwhite (SEPI))-loaded nanostructured lipid carriers (NLCs) as a new antimelanogenesis compound.
Mohadeseh Sadat Vaziri +5 more
doaj +1 more source
Aptamers and aptamer targeted delivery [PDF]
RNA Biology, 2009 When aptamers first emerged almost two decades ago, most were RNA species that bound and tagged or inhibited simple target ligands. Very soon after, the 'selectionologists' developing aptamer technology quickly realized more potential for the aptamer.
Amy C, Yan, Matthew, Levy
openaire +2 more sources
Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside
Pharmaceuticals, 2020 The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes.
Muhammad Imran Sajid +4 more
doaj +1 more source
Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12
Molecular Therapy: OncologyOncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to ...
Cheyne Kurokawa +21 more
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Molecules, 2018 We have previously evaluated and reported numerous classes of linear and cyclic peptides containing hydrophobic and hydrophilic segments for intracellular delivery of multiple molecular cargos.
Amir Nasrolahi Shirazi +4 more
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Molecules, 2020 We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation
Eman H. M. Mohammed +6 more
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Mitochondria-Targeted Drug Delivery [PDF]
Pharmaceutics, 2022 Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centres [...]
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source