Results 11 to 20 of about 573,850 (267)
Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
Pharmaceutics, 2023 RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging.
Dindyal Mandal +6 more
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Targeting delivery in Parkinson's disease [PDF]
Drug Discovery Today, 2016 Disease-modifying therapies for Parkinson's disease (PD), with the potential to halt the neurodegenerative process and to stimulate the protection, repair, and regeneration of dopaminergic neurons, remain a vital but unmet clinical need. Targeting the delivery of current and new therapeutics directly to the diseased brain region (in particular the ...
Newland, Ben +2 more
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Cells, 2022 Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application.
Khalid Zoghebi +3 more
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The roles of microRNA families in hepatic fibrosis
Cell & Bioscience, 2017 When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang +4 more
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Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds
Molecules, 2023 The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore ...
Shilpi Gupta +5 more
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Antibiotics, 2022 Bacterial resistance is a growing global concern necessitating the discovery and development of antibiotics effective against the drug-resistant bacterial strain.
Muhammad Imran Sajid +3 more
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The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells
Cell & Bioscience, 2017 Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells and involved ...
Kai Yuan +4 more
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Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter
Pharmaceutics, 2020 The cellular delivery of cell-impermeable and water-insoluble molecules remains an ongoing challenge to overcome. Previously, we reported amphipathic cyclic peptides c[WR]4 and c[WR]5 consisting of alternate arginine and tryptophan residues as nuclear ...
Sumit Kumar +5 more
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Theranostic barcoded nanoparticles for personalized cancer medicine
Nature Communications, 2016 Determining the most effective treatment for each cancer patient is a key challenge in cancer therapy. In this article, the authors show, in a mouse model of breast cancer, that DNA barcoded nanoparticles can be used for pre-screening the efficacy of ...
Zvi Yaari +11 more
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Targeted Delivery of Nanomedicines [PDF]
ISRN Pharmacology, 2012 The role of targeting of the diseased region by a drug is emphasized. The rationale for resorting to nanomaterials as drug carriers is explained. A clear understanding of the biological environment, its degradation in diseased condition, and the interaction of the drug with it in normal condition and during illness lie at the core of successful drug ...
openaire +2 more sources