Results 1 to 10 of about 573,850 (267)

The therapeutic potential of colchicine in oncology studies: from structural modification and targeted delivery to clinical management [PDF]

Frontiers in Pharmacology
Colchicine, a classical microtubule-targeting agent (MTA), exhibits remarkable anti-tumor potential, but its clinical translation is severely restricted by a narrow therapeutic window, systemic off-target toxicity, and complex pharmacokinetic ...
Pengyu Jin, Pengyu Jin, Pengyu Jin, Siyuan Wu, Haiping Yao, Yiran Ni, Yiran Ni, Ziang Yuan, Ziang Yuan, Ziang Yuan, Aidi Che, Aidi Che, Aidi Che, Lijuan Tian, Lijuan Tian, Lijuan Tian, Junming Li, Junming Li   +17 more
doaj   +2 more sources

Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride [PDF]

Nanomedicine Journal, 2015
Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in ...
Sahar Mohamaddoust Aliabadi, Farnaz Sadat Mirzazadeh Tekie, Omid Rajabi, Mohammad Reza Abbaspour, Elham Khodaverdi   +4 more
doaj   +1 more source

Targeted Delivery of siRNA [PDF]

BioMed Research International, 2006
Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.
Oliveira, S., Storm, G., Schiffelers, R.M.   +2 more
openaire   +4 more sources

Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma

Molecules, 2022
Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors and ...
Razan Alhazmi, Shirley Tong, Shaban Darwish, Elina Khanjani, Bharti Khungar, Swati Chawla, Zhonghui Zheng, Richard Chamberlin, Keykavous Parang, Sun Yang   +9 more
doaj   +1 more source

The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis.
Lin-Yan Wan, Hu Peng, Yi-Ran Ni, Xue-Ping Jiang, Jiao-Jiao Wang, Yan-Qiong Zhang, Lan Ma, Rui Li, Lin Han, Yong Tan, Jun-Ming Li, Wen-Li Cai, Wen-Fang Yuan, Jia-Jie Liang, Lu Huang, Xu Wu, Quan Zhou, Qi-Ni Cheng, Xue Yang, Meng-Yuan Liu, Wen-Bing Ai, Chang-Bai Liu, Hongbing Zhang, Jiang-Feng Wu   +23 more
doaj   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents

Pharmaceuticals, 2023
The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins.
Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Advanced NanoBiomed Research, 2022
Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell.
Maria Poley, Gal Chen, Noga Sharf-Pauker, Aviram Avital, Maya Kaduri, Mor Sela, Patricia Mora Raimundo, Lilach Koren, Sivan Arber, Egor Egorov, Janna Shainsky, Jeny Shklover, Avi Schroeder   +12 more
doaj   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents

Cells, 2022
A series of cyclic peptides, [(DipR)(WR)4], [(DipR)2(WR)3], [(DipR)3(WR)2], [(DipR)4(WR)], and [DipR]5, and their linear counterparts containing arginine (R) as positively charged residues and tryptophan (W) or diphenylalanine (Dip) as hydrophobic ...
David Salehi, Saghar Mozaffari, Khalid Zoghebi, Sandeep Lohan, Dindyal Mandal, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery

Pharmaceutics, 2022
Recent approvals of siRNA-based products motivated the scientific community to explore siRNA as a treatment option for several intractable ailments, especially cancer.
Muhammad Imran Sajid, Dindyal Mandal, Naglaa Salem El-Sayed, Sandeep Lohan, Jonathan Moreno, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Riboflavin-Targeted Drug Delivery [PDF]

Cancers, 2020
Active targeting can improve the retention of drugs and drug delivery systems in tumors, thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are overexpressed in many cancers are promising targets. In the last decade, attention and research were mainly centered on vitamin B9 (folate) targeting; however, the focus is ...
Milita Darguzyte, Natascha Drude, Twan Lammers, Fabian Kiessling   +3 more
openaire   +3 more sources