Results 21 to 30 of about 573,850 (267)
Targeted Delivery of Amikacin into Granuloma [PDF]
American Journal of Respiratory and Critical Care Medicine, 2010 Abstract Rationale Nontuberculous mycobacterial (NTM) infection is a growing problem in the United States and remains underrecognized in the developing world. The management of NTM infections is further complicated by several factors, including the need to use high systemic doses of toxic ...
Ana, Montes-Worboys +8 more
openaire +2 more sources
Osteoblast Differentiation of Human Dental Pulp Stem Cells with Dexamethasone in-situ Forming Implant [PDF]
Journal of Mashhad Dental School, 2021 Introduction: Dental pulp stem cells (DPSCs) are known as multipotent stem cells which differentiate into three different cell lines, including osteocytes, chondrocytes, and adipocytes.
Zahra Tayarani-Najaran +5 more
doaj +1 more source
Preparation and evaluation of electrospun nanofibers containing pectin and time-dependent polymers aimed for colonic drug delivery of celecoxib [PDF]
Nanomedicine Journal, 2016 Objective(s):The aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib.
A. Akhgari, M. Hossein Rotubati
doaj +1 more source
Preparation and in-vitro evaluation of fluorometholone cubosomes for ocular delivery [PDF]
Nanomedicine Journal, 2023 Objective(s): In this study, ocular drug delivery systems with a dispersed lipid liquid crystal (cubosomes) containing fluorometholone were used for sustained release and increased permeability to the eye.Materials and Methods: To obtain the best ...
Bizhan Malaekeh-Nikouei +4 more
doaj +1 more source
Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
Scientific Reports, 2017 Tumor-targeted carriers provide efficient delivery of chemotherapeutic agents to tumor tissue. CGKRK is one of the well-known tumor targeting peptides with significant specificity for angiogenic blood vessels and tumor cells. Here, we designed fatty acyl
Meenakshi Sharma +5 more
doaj +1 more source
Molecules, 2018 Linear (HR)n and cyclic [HR]n peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they ...
Naglaa Salem El-Sayed +7 more
doaj +1 more source
Molecules, 2020 Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase of SARS-COV-
Keykavous Parang +3 more
doaj +1 more source
Synthetic cells with self-activating optogenetic proteins communicate with natural cells
Nature Communications, 2022 Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.
Omer Adir +15 more
doaj +1 more source
Aptamer-targeted Antigen Delivery [PDF]
Molecular Therapy, 2014 Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells.
Wengerter, Brian C +6 more
openaire +3 more sources
Molecules, 2019 Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed +5 more
doaj +1 more source