Results 111 to 120 of about 4,076,090 (289)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Pharmacokinetic aspects of retinal drug delivery [PDF]

, 2017
Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness.
Tiina Turunen, Arto Urtti, Bhattacharya, Madhushree, Kari, Otto K., Pelkonen, Laura, Richardson, Dominique, Elisa Toropainen, Madhushree Bhattacharya, Rimpelä, Anna-Kaisa Irmeli, Rimpelä, Anna Kaisa, Marco Casteleijn, Laura Pelkonen, Jaakko Itkonen, Schmitt, Mechthild, Urtti, Arto, Mika Reinisalo, Marika Ruponen, Lajunen, Tatu, Heidi Kidron, Antopolsky, Maxim, Toropainen, Elisa, Casteleijn, Marco; id_orcid, Heikkinen, Emma, Itkonen, Jaakko, del Amo, Eva M., Mechthild Schmitt, Reinisalo, Mika, Dominique Richardson, Emma Heikkinen, Otto K. Kari, Subrizi, Astrid, Anna-Kaisa Rimpelä, Vellonen, Kati Sisko, Casteleijn, Marco G., Kati-Sisko Vellonen, Tatu Lajunen, Turunen, Tiina, Kidron, Heidi, Astrid Subrizi, Eva M. del Amo, Eva Ramsay, Ruponen, Marika, Maxim Antopolsky, Ramsay, Eva, Vellonen, Kati-Sisko, Casteleijn, Marco   +45 more
core   +1 more source

Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery

Pharmaceuticals
Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery.
Mrigank Shekhar Rai, Muhammad Imran Sajid, Jonathan Moreno, Keykavous Parang, Rakesh Kumar Tiwari   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Decationized polyplexes for targeted delivery of nucleic acids: from carrier design to in vivo evaluation [PDF]

, 2014
Gene therapy is considered a promising treatment for current intractable diseases. However, the clinical applicability of gene therapy is highly dependent on the development of safe and efficient gene delivery vectors.
Pharmaceutics, Sub Drug delivery, Novo, Luís, Sub General Pharmaceutics   +3 more
core  

Impact of stereochemical replacement on activity and selectivity of membrane-active antibacterial and antifungal cyclic peptides

npj Antimicrobials and Resistance
Herein, we report a library of 7-mer macrocyclic peptides designed by systematically replacing one, multiple, or all L-amino acids with their D-isomers in our previously identified hit compounds. Lead peptides, 15c and 16c, showed broad-spectrum activity
Sandeep Lohan, Anastasia G. Konshina, Eman H. M. Mohammed, Naiera M. Helmy, Srishhti K. Jha, Rakesh Kumar Tiwari, Innokentiy Maslennikov, Roman G. Efremov, Keykavous Parang   +8 more
doaj   +1 more source

TrkB-enhancer facilitates functional recovery after traumatic brain injury

Scientific Reports, 2017
Brain-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), suggesting that stimulation of BDNF signaling pathways may facilitate functional recovery.
John Marshall, Joanna Szmydynger-Chodobska, Mengia S. Rioult-Pedotti, Kara Lau, Andrea T. Chin, Siva K. Reddy Kotla, Rakesh Kumar Tiwari, Keykavous Parang, Steven W. Threlkeld, Adam Chodobski   +9 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy

Asian Journal of Pharmaceutical Sciences
Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic acid drugs, can silence the mRNAs of tumor-associated ...
Xiaoxin Yan, Jinhu Liu, Jie Liu, Suyun Wei, Ruixin Li, Weiwei Mu, Na Zhang, Yongjun Liu   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source