Results 131 to 140 of about 7,670,364 (343)

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Emerging Role of Metabolomics in Ovarian Cancer Diagnosis

, 2020
Ovarian cancer is considered a silent killer due to the lack of clear symptoms and efficient diagnostic tools that often lead to late diagnoses. Over recent years, the impelling need for proficient biomarkers has led researchers to consider metabolomics,
Gianmaria Miolo, Asia Saorin, Agostino Steffan, Giuseppe Corona, Emanuela Di Gregorio   +4 more
core   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Fundamental and Translational Applications of LC-MS/MS Based Metabolomics in Infectious Diseases

, 2022
Metabolomics is the study of small molecules (metabolites)
Dean, Danya
core  

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Targeted bile acid metabolomics

Targeted bile acid metabolomics measured human and mice major bile acids with their respective glycine and taurine ...
chu, lingju
core   +1 more source

A Data Mining Metabolomics Exploration of Glaucoma

, 2020
Glaucoma is an age related disease characterized by the progressive loss of retinal ganglion cells, which are the neurons that transduce the visual information from the retina to the brain. It is the leading cause of irreversible blindness worldwide.
Gohier, Philippe, Guehlouz, Khadidja, Leruez, Stéphanie, Jeanne Muller, Vincent Procaccio, Bocca, Cinzia, Guy Lenaers, Milea, Dan, Philippe Gohier, Procaccio, Vincent, Lenaers, Guy, Gilles Simard, Pascal Reynier, Chao de La Barca, Juan, Manuel, Muller, Jeanne, Simard, Gilles, Stéphanie Leruez, Judith Kouassi Nzoughet, Kouassi Nzoughet, Judith, Dan Milea, Odile Blanchet, Blanchet, Odile, Dominique Bonneau, Bonneau, Dominique, Khadidja Guehlouz, Reynier, Pascal, Cinzia Bocca, Juan M. Chao de la Barca   +27 more
core   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Untargeted and targeted metabolomics

Integrated untargeted and targeted metabolomics to reveal the mechanisms of herbal medicine HLXLD on Alzheimer's disease , Supplementary ...
周, 薇
core   +1 more source

Metabolomics in Central Sensitivity Syndromes

, 2020
Central sensitization syndromes are a collection of frequently painful disorders that contribute to decreased quality of life and increased risk of opiate abuse.
Rodriguez-Saona, Luis, Joseph S. Miller, Hackshaw, Kevin V., Luis Rodriguez-Saona, Miller, Joseph S., Kevin V. Hackshaw   +5 more
core   +1 more source