Results 21 to 30 of about 464,369 (258)

PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy

Molecular Cancer, 2023
Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target oncoprotein which reduce binding
Jeremy M. Kelm, Deepti S. Pandey, Evan Malin, Hussein Kansou, Sahil Arora, Raj Kumar, Navnath S. Gavande   +6 more
doaj   +1 more source

Targeting DUBs to degrade oncogenic proteins [PDF]

British Journal of Cancer, 2020
Targeted protein degradation has emerged as a strategy in cancer therapy. Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase (DUB) USP10, leads to the dual degradation of spleen tyrosine kinase (SYK) and FLT3, resulting in death of AML cells.
Cremer, Anjali, Stegmaier, Kimberly
openaire   +2 more sources

N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli. [PDF]

PLoS ONE, 2016
Dynamically altering protein concentration is a central activity in synthetic biology. While many tools are available to modulate protein concentration by altering protein synthesis rate, methods for decreasing protein concentration by inactivation or ...
Karthik Sekar, Andrew M Gentile, John W Bostick, Keith E J Tyo   +3 more
doaj   +1 more source

Targeted Protein Degradation Tools: Overview and Future Perspectives

Biology, 2020
Targeted protein inactivation (TPI) is an elegant approach to investigate protein function and its role in the cellular landscape, overcoming limitations of genetic perturbation strategies.
Yuri Prozzillo, Gaia Fattorini, Maria Virginia Santopietro, Luigi Suglia, Alessandra Ruggiero, Diego Ferreri, Giovanni Messina   +6 more
doaj   +1 more source

Protein-Targeted Degradation Agents Based on Natural Products

Pharmaceuticals, 2022
Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice.
Yan Li, Yi Jia, Xiaolin Wang, Hai Shang, Yu Tian   +4 more
doaj   +1 more source

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Nature Communications
The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter, Hirotake Furihata, Darren Darren, Sarath Ramachandran, Sohini Chakraborti, Kevin Haubrich, Julie Pethe, Denzel Gonzales, Andre J. Wijaya, Maria Rodriguez-Rios, Manon Sturbaut, Dylan M. Lynch, William Farnaby, Mark A. Nakasone, David Zollman, Alessio Ciulli   +17 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

Biomaterials Research, 2023
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery
Huifang Wang, Runhua Zhou, Fushan Xu, Kongjun Yang, Liuhai Zheng, Pan Zhao, Guangwei Shi, Lingyun Dai, Chengchao Xu, Le Yu, Zhijie Li, Jianhong Wang, Jigang Wang   +12 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

BromoCatch: a self-labelling tag platform for protein modification and live cell imaging

Nature Communications
Visualizing and manipulating proteins in live cells is crucial for studying complex biological processes. Self-labelling protein (SLP) tags such as HaloTag and SNAP-tag are widely used for protein labelling, and new systems are needed to expand ...
Maria Rodriguez-Rios, Conner Craigon, Mark A. Nakasone, Gajanan Sathe, Adam G. Bond, Mark Dorward, Anthony K. Edmonds, Mark C. Norley, Robert E. Arnold, Paul M. Wood, Stephen J. Reynolds, Joel O. Cresser-Brown, Graham P. Marsh, Hannah J. Maple, Alessio Ciulli   +14 more
doaj   +1 more source