Results 21 to 30 of about 714,957 (298)

Cezanne regulates E2F1-dependent HIF2α expression [PDF]

, 2015
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun, Bangoura, Baudino, Bento, Bett, Bremm, Bremm, Bremm, Budhavarapu, Chiavarina, Cox, Enesa, Fandrey, Fraile, Gordan, Gordan, Holmquist-Mengelbier, Hospenthal, Hu, Hubbi, Ivan, Jaakkola, Keith, Komander, Li, Li, Li, Linehan, Liu, Lukas, Luong, Matsumoto, Meyer, Neumann, Noguera, Pal, Pareja, Raval, Rius, Schumm, Scrideli, Semenza, Shen, Stevens, Troilo, van Uden, Wada, Webster, Yu   +48 more
core   +4 more sources

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]

, 2014
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results
Armand, Lucie, Aude-Garcia, Catherine, Carrière, Marie, Collin-Faure, Véronique, Diemer, Hélène, Gerdil, Adèle, Habert, Aurélie, Hanau, Daniel, Herlin, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +13 more
core   +4 more sources

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies [PDF]

, 2017
The ubiquitin-proteasome system is a master regulator of protein homeostasis, by which proteins are initially targeted for poly-ubiquitination by E3 ligases and then degraded into short peptides by the proteasome.
Alessio Ciulli, Bachmair, Balchin, Basham, Bondeson, Buckley, Buckley, Bulatov, Bullock, Calderon Villalobos, Caramelo, Chamberlain, Chang, Choi, Ciechanover, Condon, DaRosa, Davies, Deshaies, Dou, Elumalai, Feng, Finley, Fischer, Fischer, Frost, Galdeano, Guharoy, Hao, Hennighausen, Herhaus, Hershko, Hon, Ito, Ito, Ivan, Jaakkola, Jiang, Komander, Kraft, Kronke, Kussie, Lai, Lo, Loenarz, Long, Lu, Lu, Matyskiela, Min, Natsume, Neklesa, Nishimura, Orlicky, Orlicky, Petroski, Petzold, Rao, Ravid, Reinhardt, Riedl, Roman-Hernandez, Schuenemann, Sheard, Shi, Skaar, Sriram, Tan, Tasaki, Taxis, Toure, Van Molle, Varshavsky, Vu, Welcker, Wilkins, Winter, Wu, Xavier Lucas, Xie, Zengerle   +80 more
core   +2 more sources

"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]

, 2007
Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core   +1 more source

The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]

, 2016
Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M, Bentayebi, K, Hajitou, A, Przystal, J, Suwan, K, Tsafa, E   +5 more
core   +2 more sources

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Prion degradation pathways: Potential for therapeutic intervention [PDF]

, 2015
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
Goold, R, McKinnon, C, Tabrizi, SJ
core   +1 more source

Targeted protein degradation: expanding the toolbox [PDF]

Nature Reviews Drug Discovery, 2019
Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system represent a new therapeutic modality and are the focus of great interest, owing to potential advantages over traditional occupancy-based inhibitors with respect to dosing, side effects, drug resistance and ...
Schapira, M, Calabrese, M, Bullock, A, Crews, C   +3 more
openaire   +2 more sources

Modulation of plant autophagy during pathogen attack [PDF]

, 2017
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O., Duggan, Cian, Leary, Alexandre Y, Pandey, Pooja, Salguero Linares, Jose, Sanguankiattichai, Nattapong, Savage, Zachary D, Segretin, Maria Eugenia, Tumtas, Yasin, Yow, Rui Jin   +9 more
core   +1 more source

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source