Results 41 to 50 of about 714,957 (298)

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity [PDF]

, 2014
During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis.
Debnath, Jayanta, Giampazolias, Evangelos, Green, Douglas R., Haller, Martina, Hock, Andreas K., Oberst, Andrew, Ryan, Kevin M., Tait, Stephen W. G., Vousden, Karen H.   +8 more
core   +4 more sources

Plasticizer degradation by marine bacterial isolates : a proteogenomic and metabolomic characterization [PDF]

, 2020
Many commercial plasticizers are toxic endocrine-disrupting chemicals that are added to plastics during manufacturing and may leach out once they reach the environment.
Bosch, Rafael, Christie-Oleza, Joseph Alexander, Gibson, Matthew I., Wright, Robyn J.   +3 more
core   +3 more sources

The role of the UPS in cystic fibrosis [PDF]

, 2007
CF is an inherited autosomal recessive disease whose lethality arises from malfunction of CFTR, a single chloride (Cl-) ion channel protein. CF patients harbor mutations in the CFTR gene that lead to misfolding of the resulting CFTR protein, rendering it
Douglas M Cyr, Emma L Turnbull, Meredith FN Rosser   +2 more
core   +2 more sources

Targeted Protein Degradation: Principles and Applications of the Proteasome

Cells, 2023
The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities).
Yosup Kim, Eun-Kyung Kim, Yoona Chey, Min-Jeong Song, Ho Hee Jang   +4 more
doaj   +1 more source

Targeted protein degradation as an antiviral approach

Antiviral Research, 2023
Targeted protein degradation (TPD) has emerged as a new modality in drug discovery. In this approach, small molecules are used to drive degradation of the target protein of interest. Whereas most direct-acting antivirals (DAAs) inhibit or derange the activity of their viral protein targets and have occupancy-driven pharmacology, small molecules with a ...
Antara, Chakravarty, Priscilla L, Yang
openaire   +2 more sources

From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology

Interdisciplinary Medicine, 2023
Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD) technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells.
Xuyang Zhao, Yifan Chen, Huang Su, Liqin Zhang   +3 more
doaj   +1 more source

Targeted protein degradation in cancers: Orthodox PROTACs and beyond

The Innovation, 2023
Targeted protein degradation (TPD) is emerging as a strategy to overcome the limitations of traditional small-molecule inhibitors. Proteolysis-targeting chimera (PROTAC) technology can be used to target proteins by hijacking the ubiquitin-proteasome ...
Jin Li, Xinxin Chen, Aiping Lu, Chao Liang   +3 more
doaj   +1 more source

Research advances in targeted protein degradation technologies [PDF]

Yixue xinzhi zazhi
Targeted protein degradation (TPD) technologies leverage the body’s innate protein degradation systems to selectively eliminate protein of interest (POI).
PI Chuan, HAO Xuanrun, XIAO Haiting, LUO Xing, ZHANG Qixiong   +4 more
doaj   +1 more source

Isolation and characterization of Alicycliphilus denitrificans strain BC, which grows on benzene with chlorate as the electron acceptor [PDF]

, 2008
A bacterium, strain BC, was isolated from a benzene-degrading chlorate-reducing enrichment culture. Strain BC degrades benzene in conjunction with chlorate reduction.
Broeke, H., ten, Doesburg, W.C.J., van, Gerritse, J., Junca, H., Kieboom, C., van den, Langenhoff, A.A.M., Stams, A.J.M., Tan, N.C.G., Weelink, S.A.B.   +8 more
core   +2 more sources

Molecular genetics of auxin signaling [PDF]

, 2002
The plant hormone auxin is a simple molecule similar to tryptophan, yet it elicits a diverse array of responses and is involved in the regulation of growth and development throughout the plant life cycle.
Leyser, O
core   +1 more source