PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy
Molecular Cancer, 2023 Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target oncoprotein which reduce binding
Jeremy M. Kelm +6 more
doaj +1 more source
A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]
, 2013 The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica +4 more
core +3 more sources
Advances in targeted degradation of endogenous proteins [PDF]
Cellular and Molecular Life Sciences, 2019 Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding genes, transcripts, the process of translation or the protein directly.
Sascha Röth +2 more
openaire +3 more sources
N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli. [PDF]
PLoS ONE, 2016 Dynamically altering protein concentration is a central activity in synthetic biology. While many tools are available to modulate protein concentration by altering protein synthesis rate, methods for decreasing protein concentration by inactivation or ...
Karthik Sekar +3 more
doaj +1 more source
Protein-Targeted Degradation Agents Based on Natural Products
Pharmaceuticals, 2022 Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice.
Yan Li +4 more
doaj +1 more source
The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]
, 2009 When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Richard S. Marshall +69 more
core +1 more source
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis [PDF]
, 2012 Despite extensive understanding of sleep regulation, the molecular-level cause and function of sleep are unknown. I suggest that they originate in individual neurons and stem from increased production of protein fragments during wakefulness.
Varshavsky, Alexander
core +1 more source
Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Biomaterials Research, 2023 Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery
Huifang Wang +12 more
doaj +1 more source
Targeted Protein Degradation Tools: Overview and Future Perspectives
Biology, 2020 Targeted protein inactivation (TPI) is an elegant approach to investigate protein function and its role in the cellular landscape, overcoming limitations of genetic perturbation strategies.
Yuri Prozzillo +6 more
doaj +1 more source
Targeted Strategies for Degradation of Key Transmembrane Proteins in Cancer
BioTech, 2023 Targeted protein degradation is an attractive technology for cancer treatment due to its ability to overcome the unpredictability of the small molecule inhibitors that cause resistance mutations.
Vehary Sakanyan +2 more
doaj +1 more source