Results 91 to 100 of about 3,528,989 (183)

Impact of correlated PBPK parameters on intra‐patient global sensitivity analysis in molecular radiotherapy

Medical Physics, Volume 53, Issue 11, November 2026.
Abstract Background Physiologically based pharmacokinetic (PBPK) models integrated into digital twins provide a robust framework for optimizing individualized molecular radiotherapy (MRT). Nevertheless, uncertainties in PBPK‐model‐derived dosimetry can compromise the reliability of dosimetry‐guided treatment planning and individualized therapy ...
Elham Yousefzadeh‐Nowshahr, Deni Hardiansyah, Valentina Vasic, Anna‐Lena Theisen, Johannes Tran‐Gia, Philipp E. Hartrampf, Ambros J. Beer, Michael Lassmann, Gerhard Glatting   +8 more
wiley   +1 more source

Radiobiology of targeted radionuclide therapy

, 2023
Avec plusieurs spécialités autorisées au cours des dernières années, la radiothérapie interne vectorisée (RIV) connaît un fort développement et traite de plus en plus de patients. Comparativement aux RIV approuvées, il y a deux décennies (e.g. Zevalin TM), les traitements sont désormais fractionnés (plusieurs injections) et s’étalent sur plusieurs mois.
openaire   +1 more source

Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates

Scientific Reports, 2017
211At is a most promising radionuclide for targeted alpha therapy. However, its limited availability and poorly known basic chemistry hamper its use.
David Teze, Dumitru-Claudiu Sergentu, Valentina Kalichuk, Jacques Barbet, David Deniaud, Nicolas Galland, Rémi Maurice, Gilles Montavon   +7 more
doaj   +1 more source

The gastrin-releasing peptide receptor in oncology: a comprehensive review of recent advances in targeted radionuclide theranostics

Frontiers in Oncology
The gastrin-releasing peptide receptor (GRPR) is aberrantly expressed in several malignancies, including prostate cancer, breast cancer, lung cancer, and gastrointestinal stromal tumors, making it an important target for molecular imaging and targeted ...
YunLong Yang, YunLong Yang, Jiang Fu, ShengJie Tang, Tao Liu, HaiYang Hu, HaiYang Guo, Long Wen, Long Wen, Yang Yang, Yang Yang, ChengKuan Liu, ChengKuan Liu, GuiYan Yi, Li Yu, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou   +18 more
doaj   +1 more source

Supplementary Data from Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter

, 2009
Supplementary Data from Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I ...
Pilar Martin-Duque (620116), Georges Vassaux (329006), Jerome Burnet (381784), Nick R. Lemoine (9235235), Sophie Conchon (2825744), Cécilia Hindorf (14975455), Richard Iggo (292501), Miguel Quintanilla (8259348), Kevin Harrington (371839), Patrick Baril (4020668), Inge Peerlinck (14889672), Mohan Hingorani (14889666), Andrew Merron (14889669)   +12 more
core   +1 more source

Gastrin-releasing peptide receptor (GRPR) as a novel biomarker and therapeutic target in prostate cancer

Annals of Medicine
Aim: This comprehensive review aims to explore the potential applications of Gastrin-releasing peptide receptor (GRPR) in the diagnosis and treatment of prostate cancer.
Honghu Zhang, Lin Qi, Yi Cai, Xiaomei Gao   +3 more
doaj   +1 more source

Radionuclide-Labeled Biomaterials: A Novel Strategy for Tumor-Targeted Therapy

Biomimetics
This paper presents a comprehensive review of recent advancements in radionuclide-labeled biomaterials for cancer therapy, with a particular focus on the characteristics, production methods, and labeling techniques of α-particle, β-particle, and Auger ...
Shu Zhang, Aiyue Zhang, Xunhao Qi, Zongtai Han, Luqi Song, Jiayu Zhou, Guanglin Wang, Ran Zhu, Jianguo Li   +8 more
doaj   +1 more source

Radionuclide theranostics: advances and clinical applications in lung cancer

Frontiers in Oncology
Lung cancer remains a leading cause of global cancer deaths, underscoring the urgent need for more accurate diagnostic and treatment approaches. Radionuclide theranostics has rapidly emerged as a paradigm that couples molecular imaging with targeted ...
Yang Yang, Yang Yang, Jiang Fu, ShengJie Tang, Tao Liu, HaiYang Hu, HaiYang Guo, Long Wen, Long Wen, YunLong Yang, YunLong Yang, ChengKuan Liu, ChengKuan Liu, YiXin Zhang, Li Yu, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou   +18 more
doaj   +1 more source

Potential of PSMA-targeted imaging of tumors with various localizations

Бюллетень сибирской медицины
Diagnosis and therapy of malignant neoplasms are increasingly focused on the use of molecular targets involved in the multistage process of tumor pathogenesis.
A. A. Medvedeva, V. V. Vysotskaya, A. V. Muravleva, R. V. Zeltchan, A. N. Rуbina, V. E. Gol’dberg, V. I. Chernov   +6 more
doaj   +1 more source

Strategies for Innovative Development of Tumor-targeted Theranostic Radiopharmaceuticals

Yuanzineng kexue jishu
Radiopharmaceutical is an essential component of nuclear medicine and have demonstrated significant potential in disease diagnosis and treatment. In recent years, several tumor-targeted theranostic radiopharmaceuticals have been approved for market ...
HUANG Xuhu1, 2, 3, CHEN Huan1, 2, 3, LI Kexin1, 2, 3, WANG Ning1, 2, 3, ZHUANG Jin1, 2, 3, LI Hongyu1, 2, 3, DU Jin2, 3, 4
doaj   +1 more source