Results 121 to 130 of about 4,214,171 (152)

A Mathematical Modeling Approach for Targeted Radionuclide and Chimeric Antigen Receptor T Cell Combination Therapy [PDF]

Cancers, 2021
Targeted radionuclide therapy (TRT) has recently seen a surge in popularity with the use of radionuclides conjugated to small molecules and antibodies. Similarly, immunotherapy also has shown promising results, an example being chimeric antigen receptor ...
Xiuli Wang, Megan Minnix, Vikram Adhikarla   +2 more
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Association of noninvasive, radiographic measurement of prostate-specific membrane antigen (PSMA) expression with response to PSMA-targeted radionuclide therapy (TRT).

Journal of Clinical Oncology, 2019
5013 Background: Prostate surface membrane antigen (PSMA) is usually overexpressed in PC and is enriched in castration-resistant tumors. PSMA-TRT is of increasing interest to the field. Many in the field of theranostics have assumed that PSMA uptake on imaging is a pre-requisite for response.
Panagiotis J. Vlachostergios, Muhammad Junaid Niaz, Seyed Ali Mosallaie, Paul J. Christos, Amy Hackett, Joseph R. Osborne, Yuliya Jhanwar, Lauren Gracey, Ana M. Molina, David M. Nanus, Neil Harrison Bander, Scott T. Tagawa   +11 more
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Increased utilization of prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (PSMA-TRT) in African American (AA) patients at an academic medical center.

Journal of Clinical Oncology, 2023
36 Background: At Weill Cornell Medicine (WCM), we have had a research program utilizing anti-PSMA mAb J591 since the year 2000. With the addition of PSMA ligand-based therapies in 2017, we have enrolled around 300 patients on investigational PSMA-TRT clinical trials.
Joseph Earl Thomas, Jones T. Nauseef, Michael Philip Sun, Amie Patel, Angela Tan, Mahelia Bissassar, Jyothi Manohar, Kritika Subramanian, Koby Amankwah, Gabriela Madera, Ana M. Molina, Cora N. Sternberg, David M. Nanus, Neil Harrison Bander, Scott T. Tagawa   +14 more
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Phase I dose-escalation results of prostate-specific membrane antigen-targeted radionuclide therapy (PSMA-TRT) with alpha-radiolabeled antibody ²²⁵Ac-J591 and beta-radioligand ¹⁷⁷Lu-PSMA I&T.

Journal of Clinical Oncology, 2023
5018 Background: PSMA may be targeted by antibodies (mAb) or small molecules (SML), with different kinetics and biodistribution. mAb with longer circulation time and marrow exposure, but decreased access to luminal PSMA expression (e.g. salivary glands, intestine, kidney). SML diffuse to all sites of PSMA expression and then excreted.
Scott T. Tagawa, Michael Philip Sun, Jones T. Nauseef, Charlene Thomas, Sandra Huicochea Castellanos, Joseph Earl Thomas, Zachary Davidson, Judith Stangl-Kremser, Mahelia Bissassar, Jessica Palmer, Angela Tan, Amie Patel, Ana M. Molina, Cora N. Sternberg, David M. Nanus, Joseph Osborne, Neil Harrison Bander   +16 more
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Discrete beta dose kernel matrices for nuclides applied in targeted radionuclide therapy (TRT) calculated with MCNP5

Medical Physics, 2009
Purpose:Radiopharmaceuticals administered in targeted radionuclide therapy (TRT) rely to a great extent not only on beta‐emitting nuclides but also on emitters of monoenergetic electrons. Recent advances like combined PET/CT devices, the consequential coregistration of both data, the concept of using beta couples for diagnosis and therapy, respectively,
Dora, Reiner, Matthias, Blaickner, Frank, Rattay   +2 more
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A new approach for dose calculation in targeted radionuclide therapy (TRT) based on collapsed cone superposition: validation with⁹⁰Y

Physics in Medicine and Biology, 2014
To speed-up the absorbed dose (AD) computation while accounting for tissue heterogeneities, a Collapsed Cone (CC) superposition algorithm was developed and validated for (90)Y. The superposition was implemented with an Energy Deposition Kernel scaled with the radiological distance, along with CC acceleration.
Sanchez Garcia, Manuel, Gardin, Isabelle, Lebtahi, Rachida, Dieudonné, Arnaud   +3 more
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Influence of lung/soft-tissue interfaces in targeted radionuclide therapy (TRT) dosimetry: Implication for the voxel-s-values (VSV) fast convolution

Physica Medica, 2013
Introduction The aim of our work was to study the influence of lung/soft-tissue (L/ST) interfaces on dosimetry in Targeted Radionuclide Therapy (TRT) by fast convolution of Voxel-S-Values (VSV). Materials and methods Two simple anthropomorphic phantoms have been simulated with the Monte Carlo software tool MCNPX in order to calculate the dose ...
Srour, Ali, Gardin, Isabelle, Maurel, François, Burg, Samuel, Le Guludec, Dominique, Lebtahi, Rachida, Dieudonné, Arnaud   +6 more
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WE‐E‐214‐03: Biology and Physiology of Targeted Radionuclide Therapy (TRT)

Medical Physics, 2011
Radiolabeled agents are being developed for TRT (Targeted Radionuclide Therapy). Included in the 50 to 200 nm scale of this project are liposomes, short segments of DNA or RNA, nanoparticles and proteins. Because of possibly multiple lesion sites, these radiopharmaceuticals (RPs) are usually given by IV injection.
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WE‐EF‐BRA‐04: Evaluation of Dosimetric Uncertainties in Individualized Targeted Radionuclide Therapy (TRT) Treatment Planning Using Pre‐Clinical Data

Medical Physics, 2015
Purpose:Dosimetry for targeted radionuclide therapy (TRT) is moving away from conventional model‐based methods towards patient‐specific approaches. To address this need, a Monte Carlo (MC) dosimetry platform was developed to estimate patient‐specific therapeutic 3D dose distributions based on pre‐treatment imaging.
A Besemer, J Grudzinski, B Titz, J B Bednarz   +3 more
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Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response [PDF]

Cancers, 2019
Compared to external beam radiotherapy, targeted radionuclide therapy (TRT) allows for systemic radiation treatment of metastatic lesions. Published work on recent strategies to improve patient management and response to TRT through individualising ...
Nadia Falzone, Boon Lee, Javian Malcolm
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