Results 61 to 70 of about 6,131 (265)

Bringing Effectiveness into the Debate: A Guideline to Evaluating the Success of EU Targeted Sanctions

Central European Journal of International & Security Studies, 2010
The relevance of international sanctions has increased since the end of the Cold War as states and international organisations have resorted to this foreign policy tool more frequently than in the past.
Francesco Giumelli
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Sanctions and Economic Security: The Third-Country Dilemma

Eastern European Journal of Transnational Relations
G7 states are increasingly using economic sanctions in the conduct of their foreign policies. Such sanctions have serious impacts on third countries, even though they are not directly targeted.
Kinga Redlowska
doaj   +1 more source

Die Wirtschaftssanktionen als die Mittel der internationalen Druck während der russisch-ukrainischen Krise. Majandussanktsioonid kui rahvusvaheline survemeede: kui suured on eduvõimalused Venemaa-Ukraina kriisi puhul

Eesti Majanduspoliitilised Väitlused, 2015
To stop the conflict in Ukraine, in 2014 the European Union (EU), the United States and others western countries have introduced targeted sanctions against Russia, which where followed by countermeasures imposed by Russia.
Viljar Veebel, Raul Markus
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

International Legal Responses To Iran’s Nuclear Ambitions and Human Rights Violations: A Study Of Economic Sanctions

Al-Adalah
This study analyzes the international legal response to Iran's nuclear ambitions and human rights violations, focusing on the economic sanctions imposed by the United Nations, the United States, and the European Union.
Rizky Nur Fajar, Andri Sutrisno
doaj   +1 more source

Pipeline politics: Russian energy sanctions and the 2010 Ukrainian elections

Journal of Eurasian Studies, 2013
In early 2010, the ‘Orange Revolution’ in the Ukraine came to an end. The pro-Western President, Viktor Yushchenko, was replaced by the pro-Russian Viktor Yanukovych.
Randall E. Newnham
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source