Results 111 to 120 of about 1,721,954 (363)

Targeted Therapy of Melanoma [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2018
In recent years, the treatment of advanced melanoma has been revolutionized by the introduction of new innovative approaches, namely mutation-based targeted therapy and immune checkpoint blockade by CTLA4 and PD-1/PD-L1 inhibitors. The decade-long era of chemotherapy with very low response rates of 5-20% and short median survival rates of 6-9 months ...
openaire   +3 more sources

Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. [PDF]

, 2009
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago.
Cello, John P, Day, Lukejohn W
core  

Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma [PDF]

, 2015
Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than any other solid tumor. Metastatic melanoma treatment has considerably progressed in the past five years with the introduction of targeted therapy (BRAF and MEK ...
Amaria, Rodabe N., Cooper, Zachary A., Kim, Teresa, Reuben, Alexandre, Spencer, Christine, Wargo, Jennifer A.   +5 more
core   +1 more source

Metastatic melanoma-A review of current and future perspective [PDF]

arXiv, 2020
Metastatic Melanoma, the fifth most common cancer in the western countries and the most common malignancy diagnosed in United States present itself as the most lethal treatment resistant cancer worldwide. In addition to the reactive oxygen species(ROS), mutations in the genes encoding receptors and non-receptor tyrosine/serene/threonine protein kinases
arxiv  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Immune-mediated mechanisms influencing the efficacy of anticancer therapies [PDF]

, 2015
Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off ...
Acharyya, Affara, Ahn, Ahn, Albanesi, Alizadeh, Anders, Andreu, Apetoh, Azab, Balachandran, Bald, Begg, Borg, Bos, Broz, Bruchard, Burnette, Casares, Cavnar, Chabner, Chao, Chung, Ciampricotti, Clynes, Coffelt, Cooper, Dankort, De Palma, De Palma, De Palma, De Palma, De Palma, de Visser, de Visser, Demaria, DeNardo, DeNardo, Deng, Deng, Derksen, Devaud, DeVita, Di Maio, Di Mitri, Diaz-Montero, Dijkgraaf, Dirkx, Dranoff, Du, DuPage, DuPage, Engelhardt, Ferrari de Andrade, Finke, Fischer, Francia, Fridlender, Gabrilovich, Gabrusiewicz, Ganesan, Garbe, Germano, Ghiringhelli, Ghiringhelli, Goodman, Grugan, Guerin, Guerriero, Gupta, Guy, Guy, Hagerling, Hamid, Han, Hanahan, Hanahan, Hanna, Hannesdottir, Herbst, Highfill, Ho, Hodi, Houthuijzen, Huang, Imai, Jiang, Kanterman, Karin E. de Visser, Kioi, Kitamura, Klug, Knight, Ko, Kodumudi, Kowanetz, Koya, Kozin, Krumbhaar, Landsberg, Le, Ledford, Lee, Lesterhuis, Li, Liauw, Lin, Lin, Liu, Lutsiak, Ma, Ma, Manning, Mantovani, Maroulakou, Matsumura, Mattarollo, Mazzieri, Minard-Colin, Mitchem, Mokyr, Muller, Muller, Munoz, Murdoch, Nakasone, Nefedova, Noh, North, Noy, Ojalvo, Olive, Pahler, Pander, Pardoll, Park, Paulus, Pienta, Pollizzi, Porembka, Powell, Powles, Priceman, Pucci, Pyonteck, Qian, Quail, Rakhra, Ramakrishnan, Reits, Ries, Robert, Robert, Robert, Rolny, Ruffell, Sahu, Sandhu, Savage, Schioppa, Seth B. Coffelt, Sevko, Shevchenko, Shojaei, Shojaei, Shojaei, Shree, Shrimali, Simpson, Singh, Singh, Singh, Sistigu, Smith, Snyder, Sommer, Srivastava, Stanley, Stockmann, Straussman, Suzuki, Suzuki, Swierczak, Takeshima, Talmadge, Taskinen, Terme, Toso, Tumeh, Ugel, Vanneman, Verbrugge, Vincent, Walter, Wang, Wang, Welford, Wilmott, Wu, Wu, Xu, Xue, Yang, Youn, Zhang, Zhang, Zhu   +206 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy [PDF]

, 2015
The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy.
Bahrami, B., Bakhshaei, P., Ghalamfarsa, G., Hojjat-Farsangi, M., Jadidi-Niaragh, F., Mohammadnia-Afrouzi, M., Sadreddini, S., Yazdani, Y., Yousefi, M.   +8 more
core   +1 more source

RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

Cells
Autophagy is essential for cell survival and cellular homeostasis under various stress conditions. Therefore, autophagy dysfunction is associated with the pathogenesis of various human diseases. We explored the regulatory role of RhoBTB3 in autophagy and
Kyungho Kim, Dong-Gun Kim, Youn-Jae Kim
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source