Results 91 to 100 of about 1,156,734 (317)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Improvements in Clinical Cancer Care Associated with Integration of Personalized Medicine

Background: While adoption of personalized medicine (PM) continues to increase in clinical oncology, there is limited data connecting the level of PM adoption at a given institution to improved clinical outcomes for patients.
Daryl Pritchard, Gary G. Gustavsen, Hina Mohammed, Arushi Agarwal, Thomas D. Brown, Alissa Winzeler   +5 more
core   +1 more source

Network-targeted combination therapy : a new concept in cancer treatment

, 2004
Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index.
Liotta, Lance A., Doran, Connemara, Araujo, Robyn P., Petricoin, Emanuel F.   +3 more
core   +1 more source

Long-read sequencing identifies ATXN3 repeat expansions, and transcriptomics reveals disease progression biomarkers and druggable targets for spinocerebellar ataxia type 3

BMC Neurology
Background Hereditary ataxias (HAs) are neurodegenerative disorders characterized by progressive cerebellar degeneration, with autosomal dominant spinocerebellar ataxias (SCAs) representing the most prevalent subtype. SCA3, the most common form worldwide,
Chang Liu, Xin Wang, Chao Xu, Xiaoxiang Liu, Liyan Ke, Ying Li, Hang Zhang, Jianqiang Tan, Senwei Tan, Zitong Zhang, Liang Cheng, Yaqiong Ren, Lei Shi   +12 more
doaj   +1 more source

Apatinib for molecular targeted therapy in tumor

, 2015
Haijun Zhang Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China Abstract: As tumor angiogenesis is one of the hallmarks of cancer, the inhibition of vascular endothelial growth ...
Zhang H
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

PRMT5 Methylates and Stabilizes EphA2 via Inhibiting Its Ubiquitination and Degradation to Promote Nasopharyngeal Carcinoma Stem Cell Properties

MedComm
Both PRMT5 and EphA2 proteins are overexpressed and play a crucial role in multiple cancers, and have been used as targets to develop new anticancer drugs. However, the function and significance of the PRMT5–EphA2 interaction are unclear. Here, we report
Zheng‐Zheng Yu, Xue‐Li Mao, Shan‐Shan Lu, Ruo‐Huang Lu, Wei Zhu, Di Wu, Hong Yi, Wei Huang, Qi Wen, Guo‐Xiang Lin, Ting Zeng, Yun‐Xi Peng, Li Yuan, Ting Ran, Juan Feng, Jinwu Peng, Zhi‐Qiang Xiao   +16 more
doaj   +1 more source

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure.

, 2012
Objectives  To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is ...
Giddy, J, Olivia Keiser, Rabie, Helena, Giddy, Janet, Egger, Matthias, Wood, R, Eley, Brian, Davies, M-A, Karl Technau, Harry Moultrie, Janet Giddy, Helena Rabie, Eley, B, Robin Wood, Technau, Karl, Garone, D, Daniela Garone, Boulle, A, Technau, K, Egger, M, Matthias Egger, Keiser, Olivia, Rabie, H, Brian Eley, Moultrie, Harry, Boulle, Andrew, IeDEA, Southern Africa Collaboration, Mary-Ann Davies, Garone, Daniela, Moultrie, H, Keiser, O, Davies, Mary-Ann, Andrew Boulle, Wood, Robin   +33 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

Cells
Autophagy is essential for cell survival and cellular homeostasis under various stress conditions. Therefore, autophagy dysfunction is associated with the pathogenesis of various human diseases. We explored the regulatory role of RhoBTB3 in autophagy and
Kyungho Kim, Dong-Gun Kim, Youn-Jae Kim
doaj   +1 more source