Results 181 to 190 of about 1,817,538 (306)

Targeted Therapy for Idiopathic Inflammatory Myopathy. [PDF]

J Cachexia Sarcopenia Muscle
Wang R, Lin W, Xie Q, Yin G.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Genomic landscape of cholangiocarcinoma in India: ethnic variants and implications for targeted therapy. [PDF]

BMC Cancer
Suryavanshi M, Ostwal V, Javle M, Kumar M, Shetty O, Patil D, Sharma S, Limaye S, Patel A, Sirohi B, Bahl A, Rohtagi N.   +11 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CLDN18.2-Targeted Therapy in Gastrointestinal Cancers. [PDF]

Cancers (Basel)
Dominguez Wiscovitch A, Sanchez Mendez RJ, Chuy J.   +2 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Harnessing lentiviral vectors for in vivo gene therapy of liver metastases

Clinical and Translational Medicine
Giovanna Giacca, Luigi Naldini, Mario Leonardo Squadrito   +2 more
doaj   +1 more source

Targeted Therapy for Advanced Gastrointestinal Stromal Tumors: Evolution and Future Directions. [PDF]

Drug Des Devel Ther
Wang XD, Shou CH, Chen SC, Hong YY, Zhu KK, Yang WL, Yu JR.   +6 more
europepmc   +1 more source

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates [PDF]

, 2011
Cook, MJ, Edwards, DR, Moreno, M, Russell, DA, Stuchinskaya, T   +4 more
core   +1 more source

Targeting Epigenetic Targets for Cancer Therapy

Current Topics in Medicinal Chemistry, 2019
openaire   +2 more sources