Results 251 to 260 of about 1,721,954 (363)

A transgenic mouse line that develops early‐onset invasive gastric carcinoma provides a model for carcinoembryonic antigen‐targeted tumor therapy [PDF]

, 2000
John A. Thompson, Thomas Epting, Georg Schwarzkopf, Axel Singhofen, Anne‐Marie Eades‐Perner, Herman van der Putten, Wolfgang Zimmermann   +6 more
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy. [PDF]

Front Med (Lausanne)
Jin Y, Chen M, Chen F, Gao Z, Li X, Hu L, Cai D, Zhao S, Song Z.   +8 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Molecular mechanisms and targeted therapy of progranulin in metabolic diseases. [PDF]

Front Endocrinol (Lausanne)
Wang X, Liang Y, Yang F, Shi Y, Shao R, Jing R, Yang T, Chu Q, An D, Zhou Q, Song J, Chen H, Liu C.   +12 more
europepmc   +1 more source

Current and future antifungal therapy: new targets for antifungal therapy

, 2000
Vincent T. Andriole
openalex   +1 more source

Tumour-selective transcriptional targeting for breast cancer gene therapy [PDF]

, 2000
HC Hurst
openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy. [PDF]

Front Neurosci
Xie C, Wu N, Guo J, Ma L, Zhang C.
europepmc   +1 more source

Dihydropyrimidine dehydrogenase - a target for improved cancer therapy [PDF]

, 2000
György Schneider
openalex   +1 more source