Results 31 to 40 of about 2,058,620 (312)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Novìtnâ Osvìta, 2015 While teaching English for specific purposes (ESP) at the university, it is important to find the ways to increase students’ intrinsic motivation, so that they understood why it is important for them to learn the foreign language and how they might use ...
S. S. Kolomiets, L. O. Konoplenko
doaj +1 more source
Nursing and Midwifery Studies, 2022 Background: It is important to investigate the effectiveness of various educational methods in different cultural, educational, and clinical contexts.
Hanieh Bahadori +2 more
doaj +1 more source
Revista Linguagem & Ensino, 2022 O interesse na Aprendizagem Baseada em Tarefas (ABT) tem se renovado. Desde 2014, observam-se mudanças graduais a respeito da ABT, com vários estudos tem documentando a sinergia entre tarefas comunicativas e tecnologia. Este artigo explora tendências passadas, presentes e busca contribuir para estudos futuros dessa abordagem considerada forte no ensino
openaire +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The applicability of English language teaching methods to other subjects [PDF]
Educational Role of Language Journal, 2020 This paper reports the findings of a pilot teacher training course being delivered to teachers and teacher educators of Islamic studies subject at British Council Afghanistan.
Parwiz Hussain
doaj +1 more source
TASK-BASED LEARNING IN THE TEXTBOOK ENGLISH FOR PALESTINE
English Review: Journal of English Education, 2019 The aim of the study is to examine the ninth grade teachers' perceptions towards task-based learning (TBL) method and analyze the tasks and activities in the textbook of English for Palestine Ninth Grade. In addition, this study aims at evaluating the appropriateness and the effectiveness of TBL in the classroom.
Rasha Sameer Karaki +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2022 Origins of the Monitoring, Evaluation and Learning, Communities of Practice (CoP) & Task Force on ...
CGIAR Indicator Task Force
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