Results 71 to 80 of about 4,523,012 (337)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Distributed Reliable and Efficient Transmission Task Assignment for WSNs

Sensors, 2019
Task assignment is a crucial problem in wireless sensor networks (WSNs) that may affect the completion quality of sensing tasks. From the perspective of global optimization, a transmission-oriented reliable and energy-efficient task allocation (TRETA) is
Xiaojuan Zhu, Kuan-Ching Li, Jinwei Zhang, Shunxiang Zhang   +3 more
doaj   +1 more source

Research on Dynamic Task Allocation Algorithm to Improve User Participation in the Witkey Mode

Advances in Multimedia, 2022
The task allocation process in the Witkey mode is dynamic and open, in which Witkey is a rational person. Due to Witkey's individual rationality, in order to make the result of task allocation stable, task allocation must reach the Nash equilibrium ...
Yujie Wan, Minglan Fu, Lvqiang Chen, Debao Chen, Jiekun Li, Wei Zhou, Mengxue Liu   +6 more
doaj   +1 more source

Temporal task allocation in periodic environments. An approach based on synchronization [PDF]

, 2013
In this paper, we study a robot swarm that has to perform task allocation in an environment that features periodic properties. In this environment, tasks appear in different areas following periodic temporal patterns.
Birattari, Mauro, Brutschy, Arne, Castillo Cagigal, Manuel, Gutiérrez Martín, Álvaro   +3 more
core   +1 more source

Multi-robot task allocation problem with multiple nonlinear criteria using branch and bound and genetic algorithms

Intelligent Service Robotics, 2021
The paper proposes the formulation of a single-task robot (ST), single-robot task (SR), time-extended assignment (TA), multi-robot task allocation (MRTA) problem with multiple, nonlinear criteria using discrete variables that drastically reduce the ...
Javier G. Martin, J. R. D. Frejo, Ramón A. García, Eduardo F. Camacho   +3 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A new method of task aggregation and optimization allocation for multiple groups collaborative task networks

Scientific Reports
As task diversity and inter-task relationship complexity grow, optimal formation power allocation is key to improving task execution efficiency. This paper proposes a task optimization allocation method with multiple groups collaboration, constructing a ...
WeiWei Du, XiaoWei Chen
doaj   +1 more source

Energy-efficient task allocation for distributed applications in Wireless Sensor Networks [PDF]

, 2011
We consider the scenario of a sensing, computing and communicating infrastructure with a a programmable middleware that allows for quickly deploying different applications running on top of it so as to follow the changing ambient needs.
Atzori L, Pilloni V
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Multi-Agent Cross-Domain Collaborative Task Allocation Problem Based on Multi-Strategy Improved Dung Beetle Optimization Algorithm

Applied Sciences
Cross-domain cooperative task allocation is a complex and challenging issue in the field of multi-agent task allocation that requires urgent attention.
Yuxiang Zhou, Faxing Lu, Junfei Xu, Ling Wu   +3 more
doaj   +1 more source