Results 101 to 110 of about 2,533,411 (358)
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
International Journal of Information Systems and Project ManagementThe rapid adoption of collaboration technologies over the course of the COVID-19 pandemic, combined with the advancement, growth, and proliferation of metaverse technology capabilities, has created a heightened awareness and comfort with the use of ...
Alanah Mitchell
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Liquid Rocket Booster (LRB) for the Space Transportation System (STS) systems study. Study plan [PDF]
The two major objectives are: to present the study approach, and to provide the standard for guiding the Liquid Rocket Booster (LRB) project. The task plans provide a comprehensive description of the work to be performed.
core +1 more source
Roles in construction projects: analysis and terminology [PDF]
, 2001 Standard form contracts are typically developed through a negotiated consensus, unless they are proffered by one specific interest group. Previously published plans of work and other descriptions of the processes in construction projects tend to focus on
Hughes, Will +2 more
core
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Project Management Roles and Task for Interior Designer During Design Phase
, 2021 Nur Maizura Ahmad Noorhani +2 more
openalex +2 more sources
Management of project for automation of investment control at industrial enterprise
IOP Conference Series: Materials Science and Engineering, 2019 The article describes the issue of IT-project management at industrial enterprise under conditions of fast changing external environment. Very often projects are implemented without the necessary grounds and selection of certain IT-development task ...
O. Rostova, S. Shirokova, N. Sokolitsyna
semanticscholar +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source