Results 91 to 100 of about 478,616 (367)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Staggered chiral random matrix theory [PDF]

open access: yesPhys.Rev.D83:034505,2011, 2010
We present a random matrix theory (RMT) for the staggered lattice QCD Dirac operator. The staggered RMT is equivalent to the zero-momentum limit of the staggered chiral Lagrangian and includes all taste breaking terms at their leading order. This is an extension of previous work which only included some of the taste breaking terms. We will also present
arxiv   +1 more source

Umami as an ‘Alimentary’ Taste. A New Perspective on Taste Classification

open access: yesNutrients, 2019
Applied taste research is increasingly focusing on the relationship with diet and health, and understanding the role the sense of taste plays in encouraging or discouraging consumption.
I. Hartley, D. Liem, R. Keast
semanticscholar   +1 more source

The Taste of Carbonation [PDF]

open access: yesScience, 2009
Gee Fizz The next time you enjoy a carbonated beverage, you can do so with an enhanced understanding of the molecular mechanism that provides its distinctive flavor sensation. Chandrashekar et al. (p.
Chandrashekar, Jayaram   +6 more
openaire   +5 more sources

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough

open access: yesERJ Open Research, 2023
Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because the gustatory nerves innervating taste buds express this same family of ...
Brigit High   +8 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Pregnant women exhibit decreased trigeminal sensitivity

open access: yesBrain and Behavior
Introduction Chemosensory function in pregnant women is far from being fully understood due to the lack of data and inconsistencies between the results of self‐reports and objective studies. Methods In the present study in pregnant and non‐pregnant women
Agnieszka Sabiniewicz   +2 more
doaj   +1 more source

Spatiotemporal Changes in Transcriptome of Odontogenic and Non-odontogenic Regions in the Dental Arch of Mus musculus

open access: yesFrontiers in Cell and Developmental Biology, 2021
Over the past 40 years, studies on tooth regeneration have been conducted. These studies comprised two main flows: some focused on epithelial–mesenchymal interaction in the odontogenic region, whereas others focused on creating a supernumerary tooth in ...
Dong-Joon Lee   +4 more
doaj   +1 more source

Fashionpedia-Ads: Do Your Favorite Advertisements Reveal Your Fashion Taste? [PDF]

open access: yesarXiv, 2023
Consumers are exposed to advertisements across many different domains on the internet, such as fashion, beauty, car, food, and others. On the other hand, fashion represents second highest e-commerce shopping category. Does consumer digital record behavior on various fashion ad images reveal their fashion taste?
arxiv  

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